Hero, Barbara, Clement, Nathalie, Ora, Ingrid ORCID: 0000-0002-3931-4125, Pierron, Gaelle, Lapouble, Eve, Theissen, Jessica, Pasqualini, Claudia, Valteau-Couanet, Dominique, Plantaz, Dominique, Michon, Jean, Delattre, Olivier, Tardieu, Marc and Schleiermacher, Gudrun (2018). Genomic Profiles of Neuroblastoma Associated With Opsoclonus Myoclonus Syndrome. J. Pediatr. Hematol. Oncol., 40 (2). S. 93 - 99. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-3678

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Abstract

Opsoclonus myoclonus syndrome (OMS), often called dancing eyed syndrome, is a rare neurological condition associated with neuroblastoma in the majority of all childhood cases. Genomic copy number profiles have shown to be of prognostic significance for neuroblastoma patients. The aim of this retrospective multicenter study was to analyze the genomic copy number profiles of tumors from children with neuroblastoma presenting with OMS at diagnosis. In 44 cases of neuroblastoma associated with OMS, overall genomic profiling by either array-comparative genomic hybridization or single nucleotide polymorphism array proved successful in 91% of the cases, distinguishing tumors harboring segmental chromosome alterations from those with numerical chromosome alterations only. A total of 23/44 (52%) tumors showed an segmental chromosome alterations genomic profile, 16/44 (36%) an numerical chromosome alterations genomic profile, and 1 case displayed an atypical profile (12q amplicon). No recurrently small interstitial copy number alterations were identified. With no tumor relapse nor disease-related deaths, the overall genomic profile was not of prognostic impact with regard to the oncological outcome in this series of patients. Thus, the observation of an excellent oncological outcome, even for those with an unfavorable genomic profile of neuroblastoma, supports the hypothesis that an immune response might be involved in tumor control in these patients with OMS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hero, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clement, NathalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ora, IngridUNSPECIFIEDorcid.org/0000-0002-3931-4125UNSPECIFIED
Pierron, GaelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lapouble, EveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Theissen, JessicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pasqualini, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valteau-Couanet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plantaz, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michon, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delattre, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tardieu, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schleiermacher, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-194243
DOI: 10.1097/MPH.0000000000000976
Journal or Publication Title: J. Pediatr. Hematol. Oncol.
Volume: 40
Number: 2
Page Range: S. 93 - 99
Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-3678
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHILDRENS CANCER GROUP; ANTINEURONAL ANTIBODIES; MYCN AMPLIFICATION; CLINICAL-RELEVANCE; PEDIATRIC ONCOLOGY; ATAXIA SYNDROME; ARRAY-CGH; SHORT ARM; B-CELL; AUTOANTIBODIESMultiple languages
Oncology; Hematology; PediatricsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19424

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