Beati, Hamze, Peek, Irina, Hordowska, Paulina, Honemann-Capito, Mona, Glashauser, Jade, Renschler, Fabian A., Kakanj, Parisa, Ramrath, Andreas, Leptin, Maria ORCID: 0000-0001-7097-348X, Luschnig, Stefan, Wiesner, Silke ORCID: 0000-0003-0015-0167 and Wodarz, Andreas ORCID: 0000-0002-0007-6289 (2018). The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. J. Cell Biol., 217 (3). S. 1079 - 1096. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

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Abstract

In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation of the ZA depends on components of the Par-atypical PKC (Par-aPKC) complex of polarity regulators. We have identified the Lin11, Isl-1, Mec-3 (LIM) protein Smallish (Smash), the orthologue of vertebrate LMO7, as a binding partner of Bazooka/Par-3 (Baz), a core component of the Par-aPKC complex. Smash also binds to Canoe/Afadin and the tyrosine kinase Src42A and localizes to the ZA in a planar polarized fashion. Animals lacking Smash show loss of planar cell polarity (PCP) in the embryonic epidermis and reduced cell bond tension, leading to severe defects during embryonic morphogenesis of epithelial tissues and organs. Overexpression of Smash causes apical constriction of epithelial cells. We propose that Smash is a key regulator of morphogenesis coordinating PCP and actomyosin contractility at the ZA.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Beati, HamzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peek, IrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hordowska, PaulinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Honemann-Capito, MonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glashauser, JadeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renschler, Fabian A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kakanj, ParisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramrath, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leptin, MariaUNSPECIFIEDorcid.org/0000-0001-7097-348XUNSPECIFIED
Luschnig, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiesner, SilkeUNSPECIFIEDorcid.org/0000-0003-0015-0167UNSPECIFIED
Wodarz, AndreasUNSPECIFIEDorcid.org/0000-0002-0007-6289UNSPECIFIED
URN: urn:nbn:de:hbz:38-194449
DOI: 10.1083/jcb.201610098
Journal or Publication Title: J. Cell Biol.
Volume: 217
Number: 3
Page Range: S. 1079 - 1096
Date: 2018
Publisher: ROCKEFELLER UNIV PRESS
Place of Publication: NEW YORK
ISSN: 1540-8140
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CADHERIN-MEDIATED ADHESION; APICAL CONSTRICTION; DROSOPHILA-MELANOGASTER; ACTOMYOSIN CONTRACTILITY; CONVERGENT EXTENSION; ACTIN CYTOSKELETON; PLANAR POLARITY; GENE-EXPRESSION; DORSAL CLOSURE; SHROOMMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19444

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