Universität zu Köln

Hagmann, H., Benzing, T. and Kurschat, C. (2018). Preeclampsia/eclampsia. Nephrologe, 13 (2). S. 127 - 137. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1862-0418

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Abstract

Preeclampsia/eclampsia is a potentially life-threatening disorder for mother and fetus. Hallmarks of the disease are a newly diagnosed hypertension > 140/90 mmHg (gestational hypertension) and proteinuria > 300 mg/24 h after completion of the 20th week of gestation. A severe course of the disease can lead to generalized seizures, kidney failure, HELLP syndrome, pulmonary edema and fetal growth retardation. In this situation, to date, prompt delivery is the only therapeutic option. Preeclampsia has recently been identified as an independent cardiovascular risk factor for the mother. In recent years exciting evidence has revealed an imbalance of angiogenic and anti-angiogenic factors to be partly responsible for the development of generalized endothelial dysfunction. The identification of these factors opens up new avenues for treatment of preeclampsia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hagmann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benzing, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschat, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194992
DOI:	10.1007/s11560-018-0228-4
Journal or Publication Title:	Nephrologe
Volume:	13
Number:	2
Page Range:	S. 127 - 137
Date:	2018
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1862-0418
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TYROSINE KINASE 1; LOW-DOSE ASPIRIN; RISK; 1ST-TRIMESTER; HYPERTENSION; METAANALYSIS; PROTEINURIA; PREVENTION; PREDICTION; MANAGEMENT Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19499