Universität zu Köln

Mannil, Manoj, Hickethier, Tilman, von Spiczak, Jochen, Baer, Matthias, Henning, Andre, Hertel, Madeleine, Schmidt, Bernhard, Flohr, Thomas, Maintz, David and Alkadhi, Hatem (2018). Photon-Counting CT High-Resolution Imaging of Coronary Stents. Invest. Radiol., 53 (3). S. 143 - 150. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0210

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Abstract

Purpose: The aim of this study was to investigate computed tomography (CT) imaging characteristics of coronary stents using a novel photon-counting detector (PCD) in comparison with a conventional energy-integrating detector (EID). Materials and Methods: In this in vitro study, 18 different coronary stents were expanded in plastic tubes of 3 mm diameter, were filled with contrast agent (diluted to an attenuation of 250 Hounsfield units [HU] at 120 kVp), and were sealed. Stents were placed in an oil-filled custom phantom calibrated to an attenuation of -100 HU at 120 kVp for resembling pericardial fat. The phantom was positioned in the gantry at 2 different angles at 0 degree and 90 degrees relative to the z axis, and was imaged in a research dual-source PCD-CT scanner. Detector subsystemA used a standard 64-row EID, while detector subsystem B used a PCD, allowing high-resolution scanning (detector pixel-size 0.250 x 0.250 mm in the isocenter). Images were obtained from both detector systems at identical tube voltage (100 kVp) and tube current-time product (100 mA), and were both reconstructed using a typical convolution kernel for stent imaging (B46f) and using the same reconstruction parameters. Two independent, blinded readers evaluated in-stent visibility and measured noise, intraluminal stent diameter, and in-stent attenuation for each detector subsystem. Differences in noise, intraluminal stent diameter, and in-stent attenuation where tested using a paired t test; differences in subjective in-stent visibility were evaluated using aWilcoxon signed-rank test. Results: Best results for in-stent visibility, noise, intraluminal stent diameter, and in-stent attenuation in EID and PCD were observed at 0-degree phantom position along the z axis, suggesting higher in-plane compared with through plane resolution. Subjective in-stent visibility was superior in coronary stent images obtained from PCD compared with EID (P < 0.001). Mean in-stent diameter was 28.8% and 8.4% greater in PCD (0.85 +/- 0.24 mm; 0.83 +/- 0.14 mm) as compared with EID acquisitions (0.66 +/- 0.21 mm; 0.76 +/- 0.13 mm) for both 0-degree and 90-degree phantom positions, respectively. Average noise was significantly lower (P < 0.001) for PCD (5 +/- 0.2 HU) compared with EID (8.3 +/- 0.2HU). The increase in in-stent attenuation (0 degree: Delta 245 +/- 163 HU vs Delta 156.5 +/- 126 HU; P = 0.006; 90 degrees: Delta 194 +/- 141 HU vs Delta 126 +/- 78 HU; P = 0.001) was significantly lower for PCD compared with EID acquisitions. Conclusions: At matched CT scan protocol settings and identical image reconstruction parameters, the PCD yields superior in-stent lumen delineation of coronary artery stents as compared with conventional EID arrays.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mannil, Manoj UNSPECIFIED UNSPECIFIED UNSPECIFIED Hickethier, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED von Spiczak, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Baer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Henning, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Hertel, Madeleine UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Flohr, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Alkadhi, Hatem UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-195131
DOI:	10.1097/RLI.0000000000000420
Journal or Publication Title:	Invest. Radiol.
Volume:	53
Number:	3
Page Range:	S. 143 - 150
Date:	2018
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-0210
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CONTRAST COMPUTED-TOMOGRAPHY; IN-VITRO EVALUATION; ARTERY STENTS; ANGIOGRAPHY; RECONSTRUCTIONS; DETECTOR Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19513