Universität zu Köln

Hamprecht, A., Morio, F., Bader, O., Le Pape, P., Steinmann, J. and Dannaoui, E. (2018). Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern? Mycopathologia, 183 (1). S. 151 - 161. DORDRECHT: SPRINGER. ISSN 1573-0832

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Abstract

Aspergillus fumigatus is the most frequent filamentous fungus isolated from respiratory specimens from patients with cystic fibrosis (CF). Triazoles are the most widely used antifungals in the treatment of allergic bronchopulmonary aspergillosis (ABPA) and invasive aspergillosis (IA) in CF patients. Treatment success could be severely compromised by the occurrence of azole-resistant A. fumigatus (ARAf), which is increasingly reported worldwide from both clinical samples and the environment. In previous studies, ARAf has been detected in up to 8% of CF patients. Isolates from CF patients requiring antifungal treatment should therefore be routinely subjected to antifungal susceptibility testing. The optimal treatment of ABPA or IA in CF patients with azole-resistant isolates has not been established; treatment options include liposomal amphotericin B i.v. and/or echinocandins i.v.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hamprecht, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morio, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bader, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Le Pape, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dannaoui, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-196626
DOI:	10.1007/s11046-017-0162-4
Journal or Publication Title:	Mycopathologia
Volume:	183
Number:	1
Page Range:	S. 151 - 161
Date:	2018
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-0832
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS; IN-VITRO SUSCEPTIBILITY; LUNG TRANSPLANTATION; TRIAZOLE RESISTANCE; ITRACONAZOLE RESISTANCE; INVASIVE ASPERGILLOSIS; INTERNATIONAL SOCIETY; FUNGAL SENSITIZATION; CLINICAL-SAMPLES; DRUG-RESISTANCE Multiple languages Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19662