Universität zu Köln

Schumann, C., Lorenz, K. and Faust, M. (2018). Hypercalcemia. Onkologe, 24 (2). S. 151 - 163. NEW YORK: SPRINGER. ISSN 1433-0415

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Abstract

Hypercalcemia is a common clinical problem. Normally, the blood serum calcium concentration is strictly regulated. Hypercalcemia results when the balance of uptake of calcium into the circulation and the excretion of calcium into the urine or deposition in bone are disturbed. The first step in the evaluation of hypercalcemia is to verify the findings with repeat measurements. In addition, albumin and protein should be measured in order to calculate the corrected calcium value. The next diagnostic step is measurement of the serum parathyroid hormone (PTH) level to differentiate parathyroid-mediated from non-parathyroid-mediated hypercalcemia. Among patients with parathyroid-related hypercalcemia, primary hyperparathyroidism (PHPT) is by far the most common cause. Patients with symptomatic PHPT should undergo surgery if possible. On the other hand a low level of intact PTH (below 20 pg/ml) is most consistent with non-parathyroid-mediated hypercalcemia. In such cases PTH-related protein (PTHrp) and vitamin D metabolites should be measured. The majority of cases with this constellation are due to tumor-related hypercalcemia. Of all cases of hypercalcemia 80-90% are due to PHPT or malignancies, whereas other potential causes of hypercalcemia are rare. If parathyroidectomy in PHPT is not desired or hypercalcemia is malignancy associated, medication forms of treatment are available.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schumann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lorenz, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faust, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-197797
DOI:	10.1007/s00761-017-0317-4
Journal or Publication Title:	Onkologe
Volume:	24
Number:	2
Page Range:	S. 151 - 163
Date:	2018
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASYMPTOMATIC PRIMARY HYPERPARATHYROIDISM; 4TH INTERNATIONAL WORKSHOP; ENDOCRINE SURGEONS ESES; EUROPEAN-SOCIETY; MANAGEMENT; GUIDELINES; STATEMENT Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19779