Stahl, Mirjam, Holfelder, Christian, Kneppo, Carolin, Kieser, Meinhard, Kasperk, Christian, Schoenau, Eckhard, Sommerburg, Olaf and Toenshoff, Burkhard (2018). FS7BJ Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis. J. Cyst. Fibros, 17 (1). S. 114 - 121. AMSTERDAM: ELSEVIER. ISSN 1873-5010

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Abstract

Background: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. Methods: In a cross-sectional study of 43 CF patients (age, 17.8 +/- 6.2 years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. Results: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25 years was reduced to 39.8% compared to 84.6% in controls (P < 0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). Conclusions: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients. (C) 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stahl, MirjamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holfelder, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kneppo, CarolinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kieser, MeinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasperk, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenau, EckhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sommerburg, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toenshoff, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-199256
DOI: 10.1016/j.jcf.2016.06.004
Journal or Publication Title: J. Cyst. Fibros
Volume: 17
Number: 1
Page Range: S. 114 - 121
Date: 2018
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1873-5010
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SOLID-ORGAN TRANSPLANTATION; VERTEBRAL FRACTURES; PROXIMAL RADIUS; MINERAL DENSITY; YOUNG-ADULTS; CHILDREN; CHILDHOOD; STRENGTH; PREDICTORS; KYPHOSISMultiple languages
Respiratory SystemMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19925

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