von Stebut, Esther and Tenzer, Stefan ORCID: 0000-0003-3034-0017 (2018). Cutaneous leishmaniasis: Distinct functions of dendritic cells and macrophages in the interaction of the host immune system with Leishmania major. Int. J. Med. Microbiol., 308 (1). S. 206 - 215. MUNICH: ELSEVIER GMBH. ISSN 1618-0607

Full text not available from this repository.

Abstract

Leishmaniasis is transmitted by sand flies leading to parasite inoculation into skin. In the mammalian host, the parasite primarily resides in skin macrophages (M Phi) and dendritic cells (DC). M Phi are silently invaded by the parasite eliciting a stress response, whereas DC become activated, release IL-12, and prime antigen-specific T cells. Here we review the basics of the immune response against this human pathogen and elucidate the role and function DC and M Phi for establishment of protective immunity against leishmaniasis. We focus on cell type specific differences in parasite uptake, phagocyte activation and processing of parasite antigens to facilitate an understanding how their respective function may be modulated e.g. under therapeutic considerations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Stebut, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tenzer, StefanUNSPECIFIEDorcid.org/0000-0003-3034-0017UNSPECIFIED
URN: urn:nbn:de:hbz:38-200561
DOI: 10.1016/j.ijmm.2017.11.002
Journal or Publication Title: Int. J. Med. Microbiol.
Volume: 308
Number: 1
Page Range: S. 206 - 215
Date: 2018
Publisher: ELSEVIER GMBH
Place of Publication: MUNICH
ISSN: 1618-0607
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CD8(+) T-CELLS; EPIDERMAL LANGERHANS CELLS; PARASITOPHOROUS VACUOLES; PERSISTENT PARASITES; IL-12 PRODUCTION; INFECTION; RELEASE; SUSCEPTIBILITY; BIOGENESIS; ACTIVATIONMultiple languages
Microbiology; VirologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20056

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item