Universität zu Köln

Mohabati, Danial, van Dijk, Elon H. C., van Rijssen, Thomas J., de Jong, Eiko K., Breukink, Myrte B., Martinez-Ciriano, Jose P., Dijkman, Greet, Hoyng, Carel B., Fauser, Sascha, Yzer, Suzanne and Boon, Camiel I. F. (2018). Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clin. Ophthalmol., 12. S. 2167 - 2177. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1177-5483

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Abstract

Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT). Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures. Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple hot spots of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit. Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mohabati, Danial UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Rijssen, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jong, Eiko K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Breukink, Myrte B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez-Ciriano, Jose P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dijkman, Greet UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Yzer, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel I. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-201305
DOI:	10.2147/OPTH.S174573
Journal or Publication Title:	Clin. Ophthalmol.
Volume:	12
Page Range:	S. 2167 - 2177
Date:	2018
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	1177-5483
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TERM-FOLLOW-UP; RETINAL-PIGMENT EPITHELIOPATHY; VISUAL-ACUITY; HALF-FLUENCE; UPDATE; PATHOPHYSIOLOGY; DEGENERATION; VARIANTS; GENE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20130