Pfaar, Oliver, Classen, Dan Philipp, Astvatsatourov, Anatoli, Klimek, Ludger and Moesges, Ralph (2018). Reliability of a New Symptom Score in a Titrated Quantitative Conjunctival Provocation Test Supported by an Objective Photodocumentation. Int. Arch. Allergy Immunol., 176 (3-4). BASEL: KARGER. ISSN 1423-0097

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Abstract

Background: Allergen provocation tests are useful methods for proving the clinical relevance of an allergen-specific sensitization. Among these methods, the conjunctival provocation test (CPT) represents an easy-to-use tool. However, its readout parameters have not yet been internationally standardized or validated. Photodocumentation has been shown as a good option for objectifying a CPT reaction, supporting the local investigator assessment. Based on test-retest reliability of the score and an objective digital photoanalysis of the conjunctival redness, this study aimed to prove the reproducibility of a new CPT scoring system for use in clinical trials (ClinicalTrials. gov identifier: NCT02690740). Methods: A titrated quantitative CPT was conducted outside of the pollen season in a final cohort of 23 adult patients with birch or grass pollen-induced allergic rhinoconjunctivitis. Conjunctival symptoms were analyzed using a standardized symptom score. Conjunctival redness was also evaluated by an external observer and correlated with a digital photoanalysis using MATLAB software. Results: A test-retest correlation of 0.6 (p < 0.01) was found for the symptom score results. Likewise, a correlation of 0.65 (p < 0.01) was observed in the digital photoanalysis. The total symptom score showed a decrease in the mean value of 0.48 score points in the retest. Conclusions: This study reveals both a valuable test-retest correlation of the proposed score as well as a good correlation of eye redness with the (objective) photodocumentation. Based on our results, we can recommend the use of this scoring system as a valuable clinical protocol for future clinical trials. (C) 2018 S. Karger AG, Basel

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, Dan PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Astvatsatourov, AnatoliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-202341
DOI: 10.1159/000487884
Journal or Publication Title: Int. Arch. Allergy Immunol.
Volume: 176
Number: 3-4
Date: 2018
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1423-0097
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALLERGIC RHINITIS; DERMATOPHAGOIDES-PTERONYSSINUS; SKIN PRICK; IMMUNOTHERAPY; INFLAMMATION; CHALLENGE; PRECISION; EFFICACY; SAFETY; ADULTSMultiple languages
Allergy; ImmunologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20234

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