Schmitz, Joel and Gouni-Berthold, Ioanna (2018). APOC-III Antisense Oligonucleotides: A New Option for the Treatment of Hypertriglyceridemia. Curr. Med. Chem., 25 (13). S. 1567 - 1577. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-533X

Full text not available from this repository.

Abstract

Elevated triglyceride levels (higher than similar to 1000 mg/dL) are associated with an increased risk for pancreatitis. Apolipoprotein-CIII (apoC-III) plays a key role in the metabolism of triglycerides and triglyceride-rich lipoproteins. Loss of function mutations in the gene encoding apoC-III (APOC3) is associated with low triglyceride levels and a decreased risk for cardiovascular disease (CVD) while overexpression of APOC3 is associated with hyper-triglyceridemia. Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apoC-III concentrations), there are many patients who still have severe hypertriglyceridemia and are at increased risk for pancreatitis and potentially for CVD. The antisense oligonucleotide (ASO) against APOC3 mRNA volanesorsen (previously called ISIS 304801, ISIS-ApoCIIIRx and IONIS-ApoCIIIRx) robustly decreases both, apoC-III production and triglyceride concentrations and is being currently evaluated in phase 3 trials. In this narrative review, we present the currently available clinical evidence on the efficacy and safety of volanesorsen for the treatment of hypertriglyceridemia.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmitz, JoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gouni-Berthold, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-202802
DOI: 10.2174/0929867324666170609081612
Journal or Publication Title: Curr. Med. Chem.
Volume: 25
Number: 13
Page Range: S. 1567 - 1577
Date: 2018
Publisher: BENTHAM SCIENCE PUBL LTD
Place of Publication: SHARJAH
ISSN: 1875-533X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
APOLIPOPROTEIN-C-III; HIGH-DENSITY-LIPOPROTEIN; OF-FUNCTION MUTATIONS; POTENTIAL MECHANISM; CARDIOVASCULAR RISK; METABOLIC SYNDROME; TRIGLYCERIDE-RICH; PLASMA; CIII; CHOLESTEROLMultiple languages
Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20280

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item