Universität zu Köln

Koehler, Felix C., Cornely, Oliver A., Wisplinghoff, Hilmar, Chang, De-Hua, Richter, Anne and Koehler, Philipp ORCID: 0000-0002-7386-7495 (2018). Candida-reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine. Mycoses, 61 (1). S. 48 - 53. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however, false negatives remain a clinical challenge. We developed a new technique measuring Candida-reactive T cells as diagnostic read-out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of a 56-year-old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy-induced neutropenia. For the first time, we provide flow cytometry-based diagnostics with Candida-reactive Tcells for invasive candidiasis with comprehensive MRI imaging. The Candida-reactive Tcell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koehler, Felix C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wisplinghoff, Hilmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, De-Hua UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehler, Philipp UNSPECIFIED orcid.org/0000-0002-7386-7495 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-205148
DOI:	10.1111/myc.12696
Journal or Publication Title:	Mycoses
Volume:	61
Number:	1
Page Range:	S. 48 - 53
Date:	2018
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ESCMID-ASTERISK GUIDELINE; EPIDEMIOLOGY; MANAGEMENT Multiple languages Dermatology; Mycology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20514