Universität zu Köln

Fiess, Achim, Koelb-Keerl, Ruth, Schuster, Alexander K., Knuf, Markus, Kirchhof, Bernd, Muether, Philipp S. and Bauer, Jacqueline (2017). Prevalence and associated factors of strabismus in former preterm and full-term infants between 4 and 10 Years of age. BMC Ophthalmol., 17. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2415

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Abstract

Background: Limited data exist collating most of the associated factors for strabismus in one analysis. The aim of this study was to assess the prevalence of strabismus and to analyse associated factors in former preterm and full-term infants. Methods: In this cross-sectional study, 239 former preterm infants with gestational age (GA) <= 32 weeks and 264 former full-term born infants with GA >= 37 weeks underwent detailed ophthalmologic examination in the age of 4-10 years and perinatal data assessment for risk factor analysis. Ophthalmologic examinations included cover testing, best corrected visual acuity, cycloplegic objective refraction, slit lamp as well as fundus examinations. For association analysis with strabismus, the following data was collected and included in multivariable analysis: sex, age at examination, anisometropia, myopic and hyperopic refractive error (>= 3 dioptres), astigmatism, birth weight percentile, gestational age, retinopathy of prematurity occurrence, maternal age at childbirth, mother smoking, breastfeeding < 3 months, artificial ventilation, intraventricular bleeding, and other perinatal adverse events. Results: Overall, 4/264 (2%) full-term infants, 15/125 (12%) preterm-infants with GA 29-32 weeks without ROP, 13/59 (22%) preterm infants with GA <= 28 weeks without ROP and 14/55 (26%) with GA <= 32 weeks with retinopathy of prematurity were affected by strabismus. In the multivariable regression model strabismus was associated with GA (OR = 0.84 per week; p = 0.001), hyperopic refractive error (OR = 4.22; p = 0.002) and astigmatism (OR = 1.68; p = 0.02). Conclusion: This investigation highlights that low gestational age and refraction of the eye are independent risk factors for strabismus, while the other factors show less independent influence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fiess, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Koelb-Keerl, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuster, Alexander K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knuf, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-208228
DOI:	10.1186/s12886-017-0605-1
Journal or Publication Title:	BMC Ophthalmol.
Volume:	17
Date:	2017
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1471-2415
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-BIRTH-WEIGHT; CHILDHOOD STRABISMUS; PREMATURE-INFANTS; RISK-FACTORS; REFRACTIVE ERRORS; GESTATIONAL-AGE; 1ST YEAR; CHILDREN; RETINOPATHY; AMBLYOPIA Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20822