Broeckelmann, Paul J., Zagadailov, Erin A., Corman, Shelby L., Chirikov, Viktor, Johnson, Courtney, Macahilig, Cynthia, Seal, Brian, Dalal, Mehul R. and Illidge, Tim (2017). Brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma who are Ineligible for autologous stem cell transplant: A Germany and United Kingdom retrospective study. Eur. J. Haematol., 99 (6). S. 553 - 559. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

ObjectiveBrentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate licensed for the treatment of relapsed/refractory Hodgkin lymphoma (rrHL) following autologous stem cell transplant (ASCT) or at least two prior therapies when ASCT or multiagent chemotherapy is not an option. The objective of this study was to describe real-world outcomes with BV in patients with rrHL considered ASCT ineligible or who refuse ASCT. MethodsThis was a retrospective medical chart review study that enrolled patients 18years old who were initially diagnosed with HL between January 1, 2008 and June 30, 2014, considered ASCT ineligible, and treated in routine care with BV for progressive disease after multidrug chemotherapy regimens. Clinical outcomes included best response to treatment, progression-free survival (PFS), overall survival (OS), and adverse events. ResultsA total of 136 patients were included, with a median age of 70years at initial HL diagnosis. The most common reasons for ASCT ineligibility werecomorbidities (74%) and age (57%). Overall response rate was 74%, and PFS and OS were 15.1 and 17.8months, respectively. Peripheral neuropathy was observed in 9.6% of patients. ConclusionThe results of this study provide real-world evidence on the feasibility and effectiveness of BV in elderly or frail ASCT-ineligible patients with rrHL in a real-world setting.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Broeckelmann, Paul J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zagadailov, Erin A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corman, Shelby L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chirikov, ViktorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnson, CourtneyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macahilig, CynthiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seal, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dalal, Mehul R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Illidge, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-210084
DOI: 10.1111/ejh.12973
Journal or Publication Title: Eur. J. Haematol.
Volume: 99
Number: 6
Page Range: S. 553 - 559
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1600-0609
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21008

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