Kiechle, Marion, Dukatz, Ricarda, Yahiaoui-Doktor, Maryam ORCID: 0000-0002-3321-1598, Berling, Anika, Basrai, Maryam, Staiger, Vera, Niederberger, Uwe ORCID: 0000-0003-3099-0183, Marter, Nicole, Lammert, Jacqueline ORCID: 0000-0002-0380-574X, Grill, Sabine, Pfeifer, Katharina, Rhiem, Kerstin, Schmutzler, Rita K., Laudes, Matthias, Siniatchkin, Michael, Halle, Martin ORCID: 0000-0003-3065-530X, Bischoff, Stephan C. and Engel, Christoph ORCID: 0000-0002-7247-282X (2017). Feasibility of structured endurance training and Mediterranean diet in BRCA1 and BRCA2 mutation carriers - an interventional randomized controlled multicenter trial (LIBRE-1). BMC Cancer, 17. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2407

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Abstract

Background: Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors. Though, randomized trials investigating the impact of lifestyle interventions on cancer prevention and prognosis in BRCA carriers are still missing. Methods: We implemented a multicenter, prospective randomized controlled trial in BRCA1/2 patients, comparing a lifestyle intervention group (IG) with a control group (CG) with the primary aim to prove feasibility. Intervention comprised a structured, individualized endurance training alongside nutrition education based on the Mediterranean diet (MD) for 3 months, plus monthly group training and regular telephone contact during the subsequent 9 months. The CG attended one session on healthy nutrition and the benefits of physical activity. Primary endpoints were feasibility, acceptance and satisfaction over 12 months. Furthermore, effects on physical fitness, diet profile, body mass index (BMI), quality of life and perceived stress were investigated. Results: Sixty-eight participants (mean age 41, mean BMI 23.2 kg/m(2)) were enrolled, of whom 55 (81%, 26 IG, 29 CG) completed 12 months. 73% (n = 26) participated in at least 70% of all intervention sessions. Predictors for drop-outs (19%; n = 13) or non-adherence (27%; n = 7) were not found. 73% rated the program highly and 80% would participate again. Severe adverse events did not occur. Positive effects in the IG compared to the CG were observed for secondary endpoints: BMI, MD eating pattern and stress levels. Conclusions: This lifestyle intervention was feasible, safe and well accepted. Positive results on eating habits, physical fitness and stress levels warrant a larger randomized trial.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kiechle, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dukatz, RicardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yahiaoui-Doktor, MaryamUNSPECIFIEDorcid.org/0000-0002-3321-1598UNSPECIFIED
Berling, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basrai, MaryamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staiger, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niederberger, UweUNSPECIFIEDorcid.org/0000-0003-3099-0183UNSPECIFIED
Marter, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammert, JacquelineUNSPECIFIEDorcid.org/0000-0002-0380-574XUNSPECIFIED
Grill, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laudes, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siniatchkin, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halle, MartinUNSPECIFIEDorcid.org/0000-0003-3065-530XUNSPECIFIED
Bischoff, Stephan C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
URN: urn:nbn:de:hbz:38-211332
DOI: 10.1186/s12885-017-3732-4
Journal or Publication Title: BMC Cancer
Volume: 17
Date: 2017
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1471-2407
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STAGE BREAST-CANCER; LIFE-STYLE INTERVENTION; PHYSICAL-ACTIVITY; ADJUVANT CHEMOTHERAPY; EUROPEAN-ORGANIZATION; POSTMENOPAUSAL WOMEN; RELATIVE VALIDITY; NUTRITION; ADULTS; RISKMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/21133

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