Universität zu Köln

Pedrosa, David J., Nelles, Christian, Brown, Peter ORCID: 0000-0002-5201-3044, Volz, Lukas J. ORCID: 0000-0002-0161-654X, Pelzer, Esther A., Tittgemeyer, Marc, Brittain, John-Stuart ORCID: 0000-0002-4172-190X and Timmermann, Lars (2017). The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake. Exp. Neurol., 297. S. 50 - 62. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2430

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Abstract

The dysregulation of endogenous rhythms within brain networks have been implicated in a broad range of motor and non-motor pathologies. Essential tremor (ET), classically the purview of a single aberrant pacemaker, has recently become associated with network-level dysfunction across multiple brain regions. Specifically, it has been suggested that motor cortex constitutes an important node in a tremor-generating network involving the cerebellum. Yet the mechanisms by which these regions relate to tremor remain a matter of considerable debate. We sought to discriminate the contributions of cerebral and cerebellar dysregulation by combining high-density electroencephalography with subject-specific structural MRI. For that, we contrasted ET with voluntary (mimicked) tremor before and after ingestion of alcohol to regulate the tremorgenic networks. Our results demonstrate distinct loci of cortical tremor coherence, most pronounced over the sensorimotor cortices in healthy controls, but more frontal motor areas in ET-patients consistent with a heightened involvement of the supplementary motor area. We further demonstrate that the reduction in tremor amplitude associated with alcohol intake is reflected in altered cerebellar - but not cerebral - coupling with movement. Taken together, these findings implicate tremor emergence as principally associated with increases in activity within frontal motor regions, whereas modulation of the amplitude of established tremor relates to changes in cerebellar activity. These findings progress a mechanistic understanding of ET and implicate network-level vulnerabilities in the rhythmic nature of communication throughout the brain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelles, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Brown, Peter UNSPECIFIED orcid.org/0000-0002-5201-3044 UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Pelzer, Esther A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Brittain, John-Stuart UNSPECIFIED orcid.org/0000-0002-4172-190X UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-212797
DOI:	10.1016/j.expneurol.2017.07.013
Journal or Publication Title:	Exp. Neurol.
Volume:	297
Page Range:	S. 50 - 62
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1090-2430
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; INDEPENDENT COMPONENT ANALYSIS; THALAMIC-STIMULATION; PARKINSONS-DISEASE; PREFRONTAL CORTEX; MOTOR CORTEX; IMAGING DATA; EEG-DATA; CEREBELLAR Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21279