Universität zu Köln

Gouni-Berthold, Ioanna (2017). The role of antisense oligonucleotide therapy against apolipoprotein-CIII in hypertriglyceridemia. Atheroscler. Suppl., 30. S. 19 - 28. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-5050

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Abstract

Increased triglyceride levels (higher than similar to 1000 mg/dL) are associated with an increased risk for pancreatitis. Apolipoprotein-CIII (apo-CIII) plays a key role in the metabolism of triglycerides and triglyceride-rich lipoproteins. While loss of function mutations in the gene encoding apo-CIII (APOC3) are associated with low triglyceride levels and a decreased risk for cardiovascular disease (CVD), overexpression of APOC3 is associated with hypertriglyceridemia. Although many drugs such as fibrates, statins and omega-3 fatty acids modestly decrease triglyceride levels (and apo-CIII concentrations), there are many patients who still have severe hypertriglyceridemia and are at risk for pancreatitis and potentially CVD. The antisense oligonucleotide (ASO) against APOC3 mRNA volanesorsen (previously called ISIS 304801, ISIS-ApoCIIIRx and IONIS-ApoCIIIRx) robustly decreases both, apo-CIII production and triglyceride concentrations and is being currently evaluated in phase 3 trials. In this narrative review we present the currently available clinical evidence on the efficacy and safety of volanesorsen for the treatment of hypertriglyceridemia. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-213294
DOI:	10.1016/j.atherosclerosissup.2017.05.003
Journal or Publication Title:	Atheroscler. Suppl.
Volume:	30
Page Range:	S. 19 - 28
Date:	2017
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-5050
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; OF-FUNCTION MUTATIONS; C-III; METABOLIC SYNDROME; FAMILIAL HYPERCHOLESTEROLEMIA; CHYLOMICRONEMIA SYNDROME; CARDIOVASCULAR-DISEASE; PLASMA TRIGLYCERIDES; POTENTIAL MECHANISM Multiple languages Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21329