Universität zu Köln

Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2017). Ready, Set. . .Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation. Mol. Syst. Biol., 13 (10). HOBOKEN: WILEY. ISSN 1744-4292

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Abstract

In embryonic stem cells (ESCs), silent genes with major developmental functions display a unique epigenetic state in which strong and broad binding by Polycomb repressive complexes (PRCs) is accompanied by the presence of poised RNA polymerase II (RNAPII) and activating histone marks (e.g. H3K4me3) (Azuara et al, 2006; Bernstein et al, 2006; Stock et al, 2007; Brookes et al, 2012). It has been suggested that the plasticity and broad differentiation potential of pluripotent cells might rely, at least partly, on this unique epigenetic state (Bernstein et al, 2006; Stock et al, 2007). In their recent study, Pombo and colleagues (Ferrai et al, 2017) show that a similar epigenetic state can be found at a subset of major developmental genes throughout the differentiation of ESCs into neurons, providing novel and exciting insights into the molecular basis of cellular plasticity in differentiated cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rada-Iglesias, Alvaro UNSPECIFIED orcid.org/0000-0001-7137-1341 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-215030
DOI:	10.15252/msb.20177968
Journal or Publication Title:	Mol. Syst. Biol.
Volume:	13
Number:	10
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1744-4292
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CPG ISLANDS; GENOME-WIDE; CELLS; ESCS Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21503