Universität zu Köln

Kevei, Eva ORCID: 0000-0002-0560-9208, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462 and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2017). Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS Lett., 591 (17). S. 2616 - 2636. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins, and is essential for cellular function, organismal growth, and viability [1,2]. Misfolded proteins that cannot be refolded by chaperone machineries are degraded by specialized proteolytic systems. A major degradation pathway regulating cellular proteostasis is the ubiquitin (Ub)/proteasome system (UPS), which regulates turnover of damaged proteins that accumulate upon stress and during aging. Despite a large number of structurally unrelated substrates, Ub conjugation is remarkably selective. Substrate selectivity is mainly provided by the group of E3 enzymes. Several observations indicate that numerous E3 Ub ligases intimately collaborate with molecular chaperones to maintain the cellular proteome. In this review, we provide an overview of specialized quality control E3 ligases playing a critical role in the degradation of damaged proteins. The process of substrate recognition and turnover, the type of chaperones they team up with, and the potential pathogeneses associated with their malfunction will be further discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kevei, Eva UNSPECIFIED orcid.org/0000-0002-0560-9208 UNSPECIFIED Pokrzywa, Wojciech UNSPECIFIED orcid.org/0000-0002-5110-4462 UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-220093
DOI:	10.1002/1873-3468.12750
Journal or Publication Title:	FEBS Lett.
Volume:	591
Number:	17
Page Range:	S. 2616 - 2636
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-QUALITY-CONTROL; HEAT-SHOCK PROTEINS; RETICULUM-ASSOCIATED DEGRADATION; NUCLEAR-MEMBRANE PROTEINS; CO-CHAPERONE; MISFOLDED PROTEINS; PROTEASOMAL DEGRADATION; TRANSCRIPTION FACTOR; PROTEOTOXIC STRESS; CARBOXYL-TERMINUS Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22009