Universität zu Köln

Hoenig, Merle Christine, Bischof, Gerard Nisal, Hammes, Jochen, Faber, Jennifer, Fliessbach, Klaus, van Eimeren, Thilo and Drzezga, Alexander (2017). Tau pathology and cognitive reserve in Alzheimer's disease. Neurobiol. Aging, 57. S. 1 - 8. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

Cognitive reserve (CR) is defined as the ability to maintain functionality despite accumulating pathology. Education has been used as a proxy for CR. For example, by using positron emission tomography imaging, higher educated Alzheimer's disease (AD) patients presented increased amyloid beta pathology than lower educated patients despite equal symptomatology. Whether similar associations exist for in vivo tau pathology remains elusive. We utilized [F-18] AV-1451 positron emission tomography imaging to examine whether high-educated AD patients (n = 12) present more severe tau pathology compared with low-educated patients (n = 12) despite equal clinical severity in regions of interest corresponding to the pathologic disease stages defined by Braak & Braak. We report tau pathology in advanced Braak stages associated with parietal and frontal regions in high-educated AD patients, whereas in low-educated AD patients tau accumulation is still confined to lower Braak stages associated with temporal and cingulate regions. Highly educated AD patients seem to be able to tolerate more tau tangle pathology than lower educated patients with comparable cognitive impairment supporting the cognitive reserve hypothesis. (C) 2017 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoenig, Merle Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Gerard Nisal UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammes, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Faber, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221270
DOI:	10.1016/j.neurobiolaging.2017.05.004
Journal or Publication Title:	Neurobiol. Aging
Volume:	57
Page Range:	S. 1 - 8
Date:	2017
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; PITTSBURGH COMPOUND-B; TELOMERE LENGTH; EDUCATION; PET; IMPACT; ASSOCIATION; DEMENTIA; RISK; PART Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22127