Smith, Patrick, Willemsen, David, Popkes, Miriam, Metge, Franziska, Gandiwa, Edson ORCID: 0000-0003-0708-350X, Reichard, Martin ORCID: 0000-0002-9306-0074 and Valenzano, Dario Riccardo ORCID: 0000-0002-8761-8289 (2017). Regulation of life span by the gut microbiota in the short-lived African turquoise killifish. eLife, 6. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Smith, PatrickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willemsen, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popkes, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metge, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gandiwa, EdsonUNSPECIFIEDorcid.org/0000-0003-0708-350XUNSPECIFIED
Reichard, MartinUNSPECIFIEDorcid.org/0000-0002-9306-0074UNSPECIFIED
Valenzano, Dario RiccardoUNSPECIFIEDorcid.org/0000-0002-8761-8289UNSPECIFIED
URN: urn:nbn:de:hbz:38-221583
DOI: 10.7554/eLife.27014
Journal or Publication Title: eLife
Volume: 6
Date: 2017
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANNUAL FISHES; CAENORHABDITIS-ELEGANS; MODEL SYSTEM; NOTHOBRANCHIUS; TRANSPLANTATION; TEMPERATURE; LONGEVITY; INSIGHTS; OBESITY; HOMEOSTASISMultiple languages
BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22158

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