Universität zu Köln

Schallenberg, Simon, Merkelbach-Bruse, Sabine and Buettner, Reinhard (2017). Lung cancer as a paradigm for precision oncology in solid tumours. Virchows Arch., 471 (2). S. 221 - 234. NEW YORK: SPRINGER. ISSN 1432-2307

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Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the western world. However, the combination of molecular genotyping and subsequent systematic treatment of decoded target structures is a prime example of precision oncology in solid tumours. In this review, current targets of approved therapeutics and potential targets in clinical and preclinical trials are outlined. Furthermore, immune checkpoint inhibitors, as promising new therapeutic options, which have already been applied successfully in cases of lung cancer, are introduced. A major issue of targeted treatment of lung tumours is the persistent development of resistance. The underlying mechanisms and established and potentially applicable alternative therapeutic approaches are described. In this process of precision oncology, immunohistochemistry, fluorescence in situ hybridization, and parallel sequencing are crucial diagnostic tools.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schallenberg, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-222786
DOI:	10.1007/s00428-017-2183-2
Journal or Publication Title:	Virchows Arch.
Volume:	471
Number:	2
Page Range:	S. 221 - 234
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-2307
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TYROSINE KINASE INHIBITORS; SOLVENT-FRONT MUTATION; IN-SITU HYBRIDIZATION; RANDOMIZED PHASE-II; SQUAMOUS-CELL; OPEN-LABEL; ACQUIRED-RESISTANCE; ANTITUMOR-ACTIVITY; ALK INHIBITOR; ROS1 REARRANGEMENTS Multiple languages Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22278