Moesges, Ralph, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942, Hucke, Hans-Peter and Joisten, Marie-Josefine (2017). Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays. Adv. Ther., 34 (8). S. 1850 - 1859. NEW YORK: SPRINGER. ISSN 1865-8652

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Abstract

Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moesges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shah-Hosseini, KijaUNSPECIFIEDorcid.org/0000-0001-9616-6942UNSPECIFIED
Hucke, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joisten, Marie-JosefineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-222793
DOI: 10.1007/s12325-017-0581-0
Journal or Publication Title: Adv. Ther.
Volume: 34
Number: 8
Page Range: S. 1850 - 1859
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1865-8652
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COMMON COLD; ALLERGIC RHINITIS; DOUBLE-BLIND; XYLOMETAZOLINE; OXYMETAZOLINE; PLACEBO; ISCHEMIA; EFFICACY; INJURY; SAFETYMultiple languages
Medicine, Research & Experimental; Pharmacology & PharmacyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22279

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