Savio, Alexandre ORCID: 0000-0002-6608-6885, Fuenger, Sarah, Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Rachakonda, Srinivas, Manoliu, Andrei, Sorg, Christian, Grimmer, Timo, Calhoun, Vince, Drzezga, Alexander, Riedl, Valentin ORCID: 0000-0002-2861-8449 and Yakushev, Igor (2017). Resting-State Networks as Simultaneously Measured with Functional MRI and PET. J. Nucl. Med., 58 (8). S. 1314 - 1318. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with F-18-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in F-18-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair tomoderate for the defaultmode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Savio, AlexandreUNSPECIFIEDorcid.org/0000-0002-6608-6885UNSPECIFIED
Fuenger, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tahmasian, MasoudUNSPECIFIEDorcid.org/0000-0003-3999-3807UNSPECIFIED
Rachakonda, SrinivasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manoliu, AndreiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorg, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimmer, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calhoun, VinceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedl, ValentinUNSPECIFIEDorcid.org/0000-0002-2861-8449UNSPECIFIED
Yakushev, IgorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-223130
DOI: 10.2967/jnumed.116.185835
Journal or Publication Title: J. Nucl. Med.
Volume: 58
Number: 8
Page Range: S. 1314 - 1318
Date: 2017
Publisher: SOC NUCLEAR MEDICINE INC
Place of Publication: RESTON
ISSN: 1535-5667
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INDEPENDENT COMPONENT ANALYSIS; GLUCOSE-UTILIZATION; HUMAN BRAIN; CONNECTIVITY; FDG; SEGMENTATION; PERFORMANCE; SELECTION; PATTERNS; TOOLMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22313

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