Universität zu Köln

Liebau, M. C. and Weber, L. T. (2017). Proteinuria in childhood. Diagnostic and therapeutic approach. Mon.schr. Kinderheilkd., 165 (8). S. 727 - 736. NEW YORK: SPRINGER. ISSN 1433-0474

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Abstract

The excretion of a nearly protein-free urine is one of the most important tasks of human kidneys. To achieve this, the glomeruli of an adult human filter around 180 l of a nearly protein-free primary urine every day. Glomerular damage is the main cause of a substantial protein loss through the kidneys, called proteinuria and needs to be distinguished from damage to the tubular system; however, proteinuria is not only a marker of renal damage but also an independent risk factor for progression of chronic kidney disease and for the development of cardiovascular complications. The exact diagnosis and therapy of proteinuria during childhood and adolescence are therefore crucial, especially in patients suffering from chronic kidney disease. This article describes a structured diagnostic approach, to give insights into the underlying pathogenesis and current therapeutic approaches of proteinuria and to outline the importance of proteinuria in daily clinical routine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Liebau, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, L. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-224219
DOI:	10.1007/s00112-017-0284-2
Journal or Publication Title:	Mon.schr. Kinderheilkd.
Volume:	165
Number:	8
Page Range:	S. 727 - 736
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BLOOD-PRESSURE CONTROL; CHRONIC KIDNEY-DISEASE; NEPHROTIC SYNDROME; COLLABORATIVE METAANALYSIS; ORTHOSTATIC PROTEINURIA; GLOMERULAR PROTEIN; HIGHER ALBUMINURIA; RENAL-FAILURE; FOLLOW-UP; PROGRESSION Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22421