Universität zu Köln

Roethlisberger, M., Strizek, B., Gottschalk, I., Mallmann, M. R., Geipel, A., Gembruch, U. and Berg, C. (2017). First-trimester intervention in twin reversed arterial perfusion sequence: does size matter? Ultrasound Obstet. Gynecol., 50 (1). S. 40 - 45. HOBOKEN: WILEY. ISSN 1469-0705

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Abstract

Objective To evaluate the outcome of first-trimester intervention (12 + 0 to 14 + 0 weeks of gestation) in pregnancies complicated by twin reversed arterial perfusion (TRAP) sequence. Methods All monochorionic diamniotic twin pregnancies diagnosed with TRAP sequence that underwent intrafetal laser ablation (IFL) of the feeding vessels before 14 + 0 weeks of gestation at the University of Bonn between 2010 and 2015 were analyzed retrospectively for intrauterine course and outcome. Results In the study period, 12 pregnancies with TRAP sequence were treated by IFL. Median gestational age at intervention was 13.2 (interquartile range (IQR), 12.6-13.6) weeks. In all cases, one intervention sufficed to disrupt the perfusion of the TRAP twin. There was no case of miscarriage, preterm prelabor rupture of membranes or hemorrhage. In five (41.7%) pregnancies, intrauterine death of the pump twin occurred at a median of 72.0 (IQR, 54.0-90.0; range, 48-96) h after intervention. The remaining seven pregnancies continued uneventfully resulting in birth of a healthy infant at term. A comparison of survivors and non-survivors identified a significant difference in median discordance between crown-rump length (CRL) of the pump twin and upper pole-rump length (URL) of the TRAP twin ((CRL-URL)/CRL ratio, 0.56 vs 0.31; P < 0.05 and URL/CRL ratio, 0.44 vs 0.68; P < 0.05). Survivors were treated at a significantly later gestational age than were non-survivors (median, 13.4 (IQR, 12.9-14.1) vs 12.6 (IQR, 12.5-13.1); P < 0.05). However, none of these parameters independently predicted survival. Conclusions Although technically feasible, IFL performed in the first trimester for TRAP sequence is associated with a significant fetal loss rate. Gestational age at intervention, (CRL-URL)/CRL ratio and URL/CRL ratio are potential predictors of pregnancy outcome. Copyright (C) 2016 ISUOG. Published by John Wiley & Sons Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roethlisberger, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Strizek, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gottschalk, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, M. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-225905
DOI:	10.1002/uog.16013
Journal or Publication Title:	Ultrasound Obstet. Gynecol.
Volume:	50
Number:	1
Page Range:	S. 40 - 45
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-0705
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERSTITIAL LASER; TRAP SEQUENCE; ACARDIAC TWIN; ANASTOMOSES; PREGNANCIES; MANAGEMENT Multiple languages Acoustics; Obstetrics & Gynecology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22590