Universität zu Köln

Duran, I., Schutz, F., Hamacher, S., Semler, O., Stark, C., Schulze, J., Rittweger, J. and Schoenau, E. (2017). The functional muscle-bone unit in children with cerebral palsy. Osteoporosis Int., 28 (7). S. 2081 - 2094. LONDON: SPRINGER LONDON LTD. ISSN 1433-2965

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Abstract

Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using only age- and height-adjusted bone mineral content (BMC) and areal bone mineral density (aBMD). When applying the functional muscle-bone unit diagnostic algorithm (FMBU-A), the prevalence of positive results decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP. The prevalence of bone health deficits in children with cerebral palsy (CP) might be overestimated because age- and height-adjusted reference percentiles for bone mineral content (BMC) and areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry (DXA) do not consider reduced muscle activity. The aim of this study was to compare the prevalence of positive DXA-based indicators for bone health deficits in children with CP to the prevalence of positive findings after applying a functional muscle-bone unit diagnostic algorithm (FMBU-A) considering reduced muscle activity. The present study was a monocentric retrospective analysis of 297 whole body DXA scans of children with CP. The prevalence of positive results of age- and height-adjusted BMC and aBMD defined as BMC and aBMD below the P3 percentile and of the FMBU-A was calculated. In children with CP, the prevalence of positive results of age-adjusted BMC were 33.3% and of aBMD 50.8%. Height-adjusted results for BMC and aBMD were positive in 16.8 and 36.0% of cases. The prevalence of positive results applying the FMBU-A regarding BMC and aBMD were significantly (p < 0.001) lower than using age- and height-adjusted BMC and aBMD (8.8 and 14.8%). Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using age- and height-adjusted BMC and aBMD. When applying the FMBU-A, the prevalence decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duran, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schutz, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamacher, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stark, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulze, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226151
DOI:	10.1007/s00198-017-4023-2
Journal or Publication Title:	Osteoporosis Int.
Volume:	28
Number:	7
Page Range:	S. 2081 - 2094
Date:	2017
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	1433-2965
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROSS MOTOR FUNCTION; PEDIATRIC OFFICIAL POSITIONS; MINERAL DENSITY; BODY-COMPOSITION; EARLY-CHILDHOOD; FRACTURES; ABSORPTIOMETRY; ADOLESCENTS; STRENGTH; MASS Multiple languages Endocrinology & Metabolism Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22615