Kuczkowski, Alexander and Brinkkoetter, Paul T. (2017). Metabolism and homeostasis in the kidney: metabolic regulation through insulin signaling in the kidney. Cell Tissue Res., 369 (1). S. 199 - 211. NEW YORK: SPRINGER. ISSN 1432-0878

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Abstract

Metabolic signaling pathways orchestrate the dynamic turnover between catabolic and anabolic processes. Thereby, they ensure the viability of the cell and assure proper function of the tissue in changing environments regarding the availability of nutrients. Yet, renal cells are not considered to be prime targets of metabolic signaling. Research of the last decade has proposed new roles of specifically altered metabolic signaling pathways. In particular, the insulin signaling cascade, a potent regulator of cellular metabolism and energy homeostasis, seems to be implicated in the progression of diabetic and non-diabetic kidney disease. The aim of this review is to summarize the current knowledge on metabolic signaling events in different renal compartments in states of health and disease. We will focus on the role of insulin signaling events and highlight recent advances in the understanding of the regulatory interplay between insulin signaling and mitochondrial function contributing to the pathogenesis of kidney disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kuczkowski, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brinkkoetter, Paul T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-226345
DOI: 10.1007/s00441-017-2619-7
Journal or Publication Title: Cell Tissue Res.
Volume: 369
Number: 1
Page Range: S. 199 - 211
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-0878
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; DIABETIC-NEPHROPATHY; RENAL-DISEASE; CELL-GROWTH; CARDIOVASCULAR-DISEASE; GLOMERULAR PODOCYTE; NEPHROTIC SYNDROME; MTORC1 ACTIVATIONMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22634

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