Hamisch, Christina, Ruge, Maximilian, Kellermann, Stephanie, Kohl, Ann-Cathrin, Duval, Inga, Goldbrunner, Roland and Grau, Stefan J. (2017). Impact of treatment on survival of patients with secondary glioblastoma. J. Neuro-Oncol., 133 (2). S. 309 - 314. NEW YORK: SPRINGER. ISSN 1573-7373

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Abstract

Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary glioblastoma evolving from previously treated lower grade gliomas between 2004 and 2015 were included. We evaluated the extent of resection, pathological parameters, adjuvant treatment, as well as survival after malignant transformation. The primary tumor grade was WHO II in 16 (41.0%) and WHO III in 23 (59.0%) patients. Median age was 43 years (range 23-67). Median KPS was 80 (range 60-100) before surgery, and 70 (range 50-100) after surgery. Gross total resection (GTR) of contrast-enhancing disease was achieved in 19 (48.7%) patients. Adjuvant treatment was radio-chemotherapy in 23 (59.0%), radiotherapy in three (7.7%), chemotherapy in five (12.8%) and none in eight (20.5%) patients. Median survival was 11 months (range 1-35) in the entire group. Time since initial diagnosis and previous treatment did not correlate with survival after glioblastoma. Failed GTR, poor KPS after surgery, and no adjuvant treatment were prognostic factors for shorter survival in univariate analysis (p < 0.0001, p = 0.028 and p = 0.003). In selected patients, complete resection and adjuvant treatment may prolong survival in spite of multiple previous therapies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hamisch, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruge, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kellermann, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kohl, Ann-CathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duval, IngaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldbrunner, RolandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grau, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-228362
DOI: 10.1007/s11060-017-2415-y
Journal or Publication Title: J. Neuro-Oncol.
Volume: 133
Number: 2
Page Range: S. 309 - 314
Date: 2017
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-7373
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RESECTION; GLIOMASMultiple languages
Oncology; Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22836

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