Universität zu Köln

Semrau, Robert (2017). The Role of Radiotherapy in the Definitive and Postoperative Treatment of Advanced Head and Neck Cancer. Oncol. Res. Treat., 40 (6). S. 347 - 353. BASEL: KARGER. ISSN 2296-5262

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Abstract

Radiotherapy plays an important role in the treatment of head and neck cancer. It represents the main curative option in advanced tumors. Due to technical progress of treatment appliances, the translation of radiobiological research into clinical praxis (altered fractionation), and the concurrent application of chemotherapy (radiochemotherapy), the efficacy of radiotherapy has markedly improved. Current developments focus on the integration of functional imaging into the treatment planning process to allow individualized dose prescription. Different systemic agents have shown to improve prognosis when applied concurrently with radiotherapy, whereas induction chemotherapy has not proven to be of further benefit. Treatment of human papillomavirus-related oropharyngeal carcinomas is challenging. Reduced treatment intensity for this entity is being investigated but cannot be recommended for clinical routine at this point. Adjuvant radiotherapy and radiochemotherapy improve the prognosis in high-risk head and neck cancer after surgical treatment. Further reductions in the treated neck volume in adjuvant radiotherapy need clinical investigation. (C) 2017 S. Karger GmbH, Freiburg

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Semrau, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-228781
DOI:	10.1159/000477128
Journal or Publication Title:	Oncol. Res. Treat.
Volume:	40
Number:	6
Page Range:	S. 347 - 353
Date:	2017
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	2296-5262
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOCALLY ADVANCED HEAD; SQUAMOUS-CELL CARCINOMA; III RANDOMIZED-TRIAL; INDUCTION CHEMOTHERAPY; HUMAN-PAPILLOMAVIRUS; RADIATION-THERAPY; ACCELERATED RADIOTHERAPY; OROPHARYNGEAL CANCER; CONCURRENT CHEMORADIOTHERAPY; CONCOMITANT CHEMOTHERAPY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22878