Universität zu Köln

Kamp, Marcel A., van Lieshout, Jasper H., Dibue-Adjei, Maxine, Weber, Jasmin K., Schneider, Toni, Restin, Tanja ORCID: 0000-0002-8816-6069, Fischer, Igor and Steiger, Hans-Jakob (2017). A Systematic and Meta-Analysis of Mortality in Experimental Mouse Models Analyzing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Transl. Stroke Res., 8 (3). S. 206 - 220. NEW YORK: SPRINGER. ISSN 1868-601X

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Abstract

Animal models are established to display the pathophysiological changes following subarachnoid hemorrhage (SAH). The aim of the present study was to determine case fatality in mouse delayed cerebral ischemia (DCI) models, to compare mortality in mouse DCI models to case fatality in human SAH patients, and to identify factors influencing mouse mortality. A systematic search of the PubMed database was performed to identify all studies that assessed mouse DCI models. Mortality rates and predictor variables were extracted and compared to the human case fatality after SAH as previously reported. Predictors for mouse mortality were identified through multivariate analysis. Forty-eight studies were included in the quantitative analysis. The mean overall mortality rate was 21% in mouse DCI models. However, the time period between induction of SAH and evaluation of mortality rates is a significant variable influencing the mortality rate in mouse SAH models. The experimental SAH model was the only significant predictor for mouse mortality after 48 h. In contrast, neither the genetic background nor the anesthetic changed the case fatality rate. Mouse mortality at 24, 48, and 72 h after experimental SAH in DCI models was significantly lower than human case fatality following aneurysmal SAH. The mean overall mortality rate in mouse DCI models is significantly lower than human case fatality following aneurysmal SAH. However, time between SAH induction and evaluation is a significant variable influencing the mortality rate in mouse SAH models. Further analyses will be required to establish whether and to which extent different DCI models affect mortality and reflect human pathophysiology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kamp, Marcel A. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Lieshout, Jasper H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dibue-Adjei, Maxine UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Jasmin K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Toni UNSPECIFIED UNSPECIFIED UNSPECIFIED Restin, Tanja UNSPECIFIED orcid.org/0000-0002-8816-6069 UNSPECIFIED Fischer, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiger, Hans-Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-229440
DOI:	10.1007/s12975-016-0513-3
Journal or Publication Title:	Transl. Stroke Res.
Volume:	8
Number:	3
Page Range:	S. 206 - 220
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1868-601X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EARLY BRAIN-INJURY; MELBOURNE STROKE INCIDENCE; CUZN-SUPEROXIDE DISMUTASE; WHITE-MATTER INJURY; CASE-FATALITY RATES; BLOOD-FLOW; SECONDARY COMPLICATIONS; VASCULAR INFLAMMATION; GENETIC ELIMINATION; BARRIER DISRUPTION Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22944