Universität zu Köln

Hartz, Annika, Pagel, Julia, Humberg, Alexander, Preuss, Michael ORCID: 0000-0001-5266-8465, Schreiter, Lena, Rupp, Jan, Figge, Julia, Karsten, Christian M., Nuernberg, Peter, Herting, Egbert, Goepel, Wolfgang and Haertel, Christoph (2017). The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. PLoS One, 12 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Objectives Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI). Methods We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge. Results We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection. Conclusions In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hartz, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Pagel, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Humberg, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Michael UNSPECIFIED orcid.org/0000-0001-5266-8465 UNSPECIFIED Schreiter, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Rupp, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Figge, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Karsten, Christian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuernberg, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-230639
DOI:	10.1371/journal.pone.0178032
Journal or Publication Title:	PLoS One
Volume:	12
Number:	5
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPLEMENT; PATHWAY; MBL; INFECTION; NEWBORNS; CHILDREN; FICOLIN; SEPSIS; GENE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23063