Universität zu Köln

Grajewski, Rafael S., Pour, Niusha Barahmand, Burian, Katja, Caramoy, Albert, Kirchhof, Bernd, Cursiefen, Claus and Heindl, Ludwig M. (2017). Analysis of the impact of allergy and atopy on new onset of uveitis. Acta Ophthalmol., 95 (3). S. E236 - 6. HOBOKEN: WILEY. ISSN 1755-3768

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Abstract

PurposeThe inappropriate immune response to harmless foreign and self-antigens is a common feature of allergy, atopy and autoimmune disease. The influence of environmental factors in the initiation of autoimmunity is not well understood. It is conceivable that immune responses to allergens may also serve as a trigger of bystander immune reactions, including autoimmunity such as uveitis. Therefore, we wanted to investigate the prevalence of allergies and atopy in patients with different types of uveitis in comparison to a control cohort. MethodsIn total, 530 consecutive patients with new-onset anterior, intermediate, posterior and panuveitis were compared to a non-uveitis control cohort consisting of 1.060 consecutive new-referral patients who attended our specialized outpatient clinics for other reasons than uveitis. Allergy and atopy status as well as demographic data (age, gender and ethnicity) were obtained by standardized interviewer-assisted questionnaires. ResultsUveitis case cohort and control cohort did not differ significantly in the allergy status (p=0.910), such as the history of pollen allergy (p=0.671), history of drug allergy (p=0.920), history of food allergy (p=0.941), history of house dust mite allergy (p=0.197) or history of other allergens (p=0.593), nor in the atopy status (p=0.802), such as the history of atopic dermatitis (p=0.365), history of asthma (p=0.430) or history of allergic rhinitis (p=0.115). ConclusionsOur results argue against a substantial influence of allergies and atopy on the onset of uveitis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grajewski, Rafael S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pour, Niusha Barahmand UNSPECIFIED UNSPECIFIED UNSPECIFIED Burian, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Caramoy, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232910
DOI:	10.1111/aos.13239
Journal or Publication Title:	Acta Ophthalmol.
Volume:	95
Number:	3
Page Range:	S. E236 - 6
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1755-3768
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELLS; ASSOCIATION; PREVALENCE; CRITERIA Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23291