Universität zu Köln

Tscherpel, Caroline, Dunkl, Veronika, Ceccon, Garry, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Judov, Natalie ORCID: 0000-0002-3909-9306, Rapp, Marion, Meyer, Philipp T., Kops, Elena Rota, Ermert, Johannes ORCID: 0000-0002-2561-7766, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Shah, Nadim J., Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Galldiks, Norbert ORCID: 0000-0002-2485-1796 (2017). The use of O-(2-F-18-fluoroethyl)-L-tyrosine PET in the diagnosis of gliomas located in the brainstem and spinal cord. Neuro-Oncology, 19 (5). S. 710 - 719. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

Despite an increasing number of O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) PET studies in supratentorial gliomas, studies regarding the usefulness of F-18-FET PET in brainstem and spinal cord gliomas to date remain scarce. Thirty-six F-18-FET PET scans were performed in 29 patients with brainstem (n = 29 scans) or spinal cord glioma (n = 7 scans). In 32 of 36 PET scans, a dynamic acquisition was performed. Fifteen scans in 15 patients were performed to assess newly diagnosed lesions, and 21 scans were obtained during follow-up: for diagnosing tumor progression (n = 15 scans in 14 patients) as well as for treatment monitoring (n = 6 scans in 3 patients). Four patients underwent additional serial scans (range, 1-2), and 3 of these 4 patients were examined for more than one indication. Maximum and mean tumor/brain ratios (TBRmax/mean) of F-18-FET uptake (20-40 min post injection) as well as kinetic F-18-FET uptake parameters were determined. Final diagnoses were confirmed histologically (54%) or by clinical follow-up (46%). In all newly diagnosed high-grade (n = 3 patients) and in 5 of 11 patients with low-grade gliomas, F-18-FET uptake was increased (TBRmax a parts per thousand 2.5 and/or TBRmean a parts per thousand 1.9). In 2 patients with newly diagnosed gliomas without MR contrast enhancement, F-18-FET PET nevertheless showed increased metabolism. At suspected progression, the combination of TBRs with kinetic F-18-FET parameters correctly identified presence or absence of progressive disease in 9 of 11 patients (82%). This preliminary study suggests that F-18-FET PET adds valuable diagnostic information in brainstem and spinal cord glioma, particularly when the diagnostic information derived from MRI is equivocal.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunkl, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ceccon, Garry UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Judov, Natalie UNSPECIFIED orcid.org/0000-0002-3909-9306 UNSPECIFIED Rapp, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Philipp T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kops, Elena Rota UNSPECIFIED UNSPECIFIED UNSPECIFIED Ermert, Johannes UNSPECIFIED orcid.org/0000-0002-2561-7766 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233473
DOI:	10.1093/neuonc/now243
Journal or Publication Title:	Neuro-Oncology
Volume:	19
Number:	5
Page Range:	S. 710 - 719
Date:	2017
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1523-5866
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; STEREOTACTIC BIOPSY; C-11 METHIONINE; MR-PET; TUMORS; NEUROONCOLOGY; GLIOBLASTOMA; CHILDREN; GLITTERS; LESIONS Multiple languages Oncology; Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23347