Universität zu Köln

Schaub, Friederike, Enders, Philip ORCID: 0000-0002-9527-4957, Bachmann, Bjoern O., Heindl, Ludwig M. and Cursiefen, Claus (2017). Effect of corneal collagen crosslinking on subsequent deep anterior lamellar keratoplasty (DALK) in keratoconus. Graefes Arch. Clin. Exp. Ophthalmol., 255 (4). S. 811 - 817. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

The purpose was to investigate the impact of ultraviolet light corneal collagen crosslinking (UV-CXL) on the success rate and clinical outcome of subsequent deep anterior lamellar keratoplasty (DALK) in eyes with keratoconus (KC). Medical records of 101 consecutive eyes with KC scheduled for big-bubble DALK surgery were screened retrospectively for details of previously performed UV-CXL, as well as intra- and postoperative complications of DALK surgery. Main outcome measures were intraoperative success rates (big-bubble formation, conversion to penetrating keratoplasty (PK)), postoperative complications, best corrected visual acuity (BCVA), endothelial cell density (ECD), and central corneal thickness (CCT) within 18 months of follow-up. Out of the 101 KC eyes, eight eyes (7.9%) had a history of previous UV-CXL. Surgical failure, defined as conversion to PK due to macroperforation, occurred in 17 eyes (16.8%) of 93 eyes without and in none with previous UV-CXL (P < .001). Failure to achieve a big-bubble occurred in 37 eyes (40.2%) without previous UV-CXL and in two eyes (25%) with previous UV-CXL. Microperforations of Descemet's membrane were observed in ten eyes (20.7%) without and in 14 eyes (15.2%) with previous UV-CXL (P = .16). No significant differences could be detected for either the postoperative complication rate (P ae .18) or the clinical outcome parameters at 18 months follow-up, including BCVA, ECD and CCT (P ae .08) for eyes with or without UV-CXL. In DALK surgery, prior UV-CXL does not seem to affect the rate of intra- or postoperative complications, the success rate, or its clinical outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Bachmann, Bjoern O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235337
DOI:	10.1007/s00417-017-3592-2
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	255
Number:	4
Page Range:	S. 811 - 817
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIG-BUBBLE TECHNIQUE; PENETRATING KERATOPLASTY; DESCEMETS-MEMBRANE; ULTRAVIOLET; RIBOFLAVIN; MICROSCOPY; LINKAGE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23533