Universität zu Köln

Popovych, Oleksandr V., Lysyansky, Borys, Rosenblum, Michael, Pikovsky, Arkady ORCID: 0000-0001-9682-7122 and Tass, Peter A. (2017). Pulsatile desynchronizing delayed feedback for closed-loop deep brain stimulation. PLoS One, 12 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

High-frequency (HF) deep brain stimulation (DBS) is the gold standard for the treatment of medically refractory movement disorders like Parkinson's disease, essential tremor, and dystonia, with a significant potential for application to other neurological diseases. The standard setup of HF DBS utilizes an open-loop stimulation protocol, where a permanent HF electrical pulse train is administered to the brain target areas irrespectively of the ongoing neuronal dynamics. Recent experimental and clinical studies demonstrate that a closed loop, adaptive DBS might be superior to the open-loop setup. We here combine the notion of the adaptive high-frequency stimulation approach, that aims at delivering stimulation adapted to the extent of appropriately detected biomarkers, with specifically desynchronizing stimulation protocols. To this end, we extend the delayed feedback stimulation methods, which are intrinsically closed-loop techniques and specifically designed to desynchronize abnormal neuronal synchronization, to pulsatile electrical brain stimulation. We show that permanent pulsatile high-frequency stimulation subjected to an amplitude modulation by linear or nonlinear delayed feedback methods can effectively and robustly desynchronize a STN-GPe network of model neurons and suggest this approach for desynchronizing closedloop DBS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Popovych, Oleksandr V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lysyansky, Borys UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenblum, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Pikovsky, Arkady UNSPECIFIED orcid.org/0000-0001-9682-7122 UNSPECIFIED Tass, Peter A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-236769
DOI:	10.1371/journal.pone.0173363
Journal or Publication Title:	PLoS One
Volume:	12
Number:	3
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COORDINATED RESET NEUROMODULATION; SUBTHALAMIC NUCLEUS STIMULATION; HIGH-FREQUENCY STIMULATION; ADVANCED PARKINSON-DISEASE; SUBJECTS MIMICKING TREMOR; STN-DBS; SYNCHRONY; MODEL; GAIT; OSCILLATIONS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23676