Universität zu Köln

Su, Jing, Wang, Dongfang ORCID: 0000-0001-8112-3149, Noerbel, Lena, Shen, Jianlei, Zhao, Zhihan, Dou, Yanzhi, Peng, Tianhuan, Shi, Jiye, Mathur, Sanjay, Fan, Chunhai ORCID: 0000-0002-7171-7338 and Song, Shiping (2017). Multicolor Gold Silver Nano-Mushrooms as Ready-to-Use SERS Probes for Ultrasensitive and Multiplex DNA/miRNA Detection. Anal. Chem., 89 (4). S. 2531 - 2539. WASHINGTON: AMER CHEMICAL SOC. ISSN 1520-6882

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Abstract

Uniform silver-containing metal nanostructures with strong and stable surface enhanced Raman scattering (SERS) signals hold great promise for developing ultrasensitive probes for biodetection. Nevertheless, the direct synthesis of such ready-to-use nanoprobes remains extremely challenging. Herein we report a DNA-mediated gold silver nanomushroom with interior nanogaps directly synthesized and used for multiplex and simultaneous SERS detection of various DNA and RNA targets. The DNA involved in the nanostructures can act as hot only gap DNA (mediated DNA) but also probe DNA (hybridized DNA), and DNA's involvement enables the nanostructures to have the inherent ability to recognize DNA and RNA targets. Importantly, we were the first to establish a new method for the generation of multicolor SERS probes using two different strategies. First Raman-labeled alkanethiol probe DNA was assembled on gold nanoparticles, and second, thiol-containing Raman reporters were coassembled with the probe DNA. The ready-to-use probes also give great potential to develop ultrasensitive detection methods for various biological molecules.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Su, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Dongfang UNSPECIFIED orcid.org/0000-0001-8112-3149 UNSPECIFIED Noerbel, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Shen, Jianlei UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Zhihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dou, Yanzhi UNSPECIFIED UNSPECIFIED UNSPECIFIED Peng, Tianhuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Jiye UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Chunhai UNSPECIFIED orcid.org/0000-0002-7171-7338 UNSPECIFIED Song, Shiping UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-239539
DOI:	10.1021/acs.analchem.6b04729
Journal or Publication Title:	Anal. Chem.
Volume:	89
Number:	4
Page Range:	S. 2531 - 2539
Date:	2017
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1520-6882
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENHANCED RAMAN-SCATTERING; PLASMONIC NANOPARTICLES; SIGNAL AMPLIFICATION; OPTICAL-PROPERTIES; INTERIOR NANOGAP; NANOSTRUCTURES; DNA; SENSOR; TAGS; NANOMATERIALS Multiple languages Chemistry, Analytical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23953