Universität zu Köln

Brocks, Tania, Fedorchenko, Oleg, Schliermann, Nicola, Stein, Astrid, Moll, Ute M., Seegobin, Seth, Dewor, Manfred, Hallek, Michael, Marquardt, Yvonne, Fietkau, Katharina, Heise, Ruth, Huth, Sebastian, Pfister, Herbert, Bernhagen, Juergen, Bucala, Richard, Baron, Jens M. and Fingerle-Rowson, Guenter (2017). Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. Faseb J., 31 (2). S. 526 - 544. BETHESDA: FEDERATION AMER SOC EXP BIOL. ISSN 1530-6860

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Abstract

The response of the skin to harmful environmental agents is shaped decisively by the status of the immune system. Keratinocytes constitutively express and secrete the chemokine-like mediator, macrophage migration inhibitory factor (MIF), more strongly than dermal fibroblasts, thereby creating a MIF gradient in skin. By using global and epidermis-restricted Mif-knockout (Mif(-1-) and K14-Cre(+ltg) ;Mif(fllft)) mice, we found that MIF both recruits and maintains antigen-presenting cells in the dermis/epidermis. The reduced presence of antigen-presenting cells in the absence of MIF was associated with accelerated and increased formation of nonmelanoma skin tumors during chemical carcinogenesis. Our results demonstrate that MIF is essential for maintaining innate immunity in skin. Loss of keratinocyte-derived MIF leads to a loss of control of epithelial skin tumor formation in chemical skin carcinogenesis, which highlights an unexpected tumor-suppressive activity of MIF in murine skin.- Brocks, T., Fedorchenko, O., Schliermann, N., Stein, A., Moll, U. M., Seegobin, S., Dewor, M., Hallek, M., Marquardt, Y., Fietkau, K., Heise, R., Huth, S., Pfister, H., Bernhagen, J., Bucala, R., Baron, J. M., Fingerle-Rowson, G. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brocks, Tania UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorchenko, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Schliermann, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Moll, Ute M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seegobin, Seth UNSPECIFIED UNSPECIFIED UNSPECIFIED Dewor, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Marquardt, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Fietkau, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Heise, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Huth, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernhagen, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Bucala, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Baron, Jens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fingerle-Rowson, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240422
DOI:	10.1096/fj.201600860R
Journal or Publication Title:	Faseb J.
Volume:	31
Number:	2
Page Range:	S. 526 - 544
Date:	2017
Publisher:	FEDERATION AMER SOC EXP BIOL
Place of Publication:	BETHESDA
ISSN:	1530-6860
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRAVIOLET-B RADIATION; FACTOR MIF; DENDRITIC CELLS; LANGERHANS CELLS; RECEPTOR COMPLEX; DNA-DAMAGE; T-CELLS; CANCER; EXPRESSION; INFLAMMATION Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24042