Universität zu Köln

Safi, Ali-Farid, Behn, Lars, Rothamel, Daniel, Guntinas-Lichius, Orlando ORCID: 0000-0001-9671-0784, Beutner, Dirk, Nickenig, Hans -Joachim, Zoeller, Joachim and Kreppel, Matthias (2017). Therapy of sinonasal malignancies invading the orbit-orbital exenteration versus preservation of the orbit plus radiotherapy. J. Cranio-MaxilloFac. Surg., 45 (2). S. 258 - 262. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Introduction: Orbital invasion is a strong independent prognostic factor for sinonasal malignancies. While there is consent about preservation of the orbit for tumors limited to the orbital periosteum there is controversy about the optimal management of sinonasal malignancies transgressing this barrier. Therefore the aim of our study was to compare exenteration versus preservation of the orbit. Material and methods: 52 patients with sinonasal malignancies invading the orbit beyond the orbital periosteum with involvement of the orbital soft tissues were included in the retrospective study. Prognostic factors were identified through univariate analysis. Results: Univariate analysis revealed a significant impact of N-classification (p = 0.017), and treatment strategy (p = 0.016). Exenteration of the orbit was associated with a significantly better 5-year overall survival rate (65.5%) than preservation of the orbit (14%). Conclusions: For patients with invasion of the structures beyond the orbital periosteum, exenteration yields better survival results than preservation of the orbital structures in combination with radiotherapy. In cases where both eyes are affected from the tumor or if only one dysfunctional eye would be left over after therapy, we do not recommend orbital exenteration because life quality would be critically deteriorated. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Behn, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Guntinas-Lichius, Orlando UNSPECIFIED orcid.org/0000-0001-9671-0784 UNSPECIFIED Beutner, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans -Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240518
DOI:	10.1016/j.jcms.2016.11.013
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	45
Number:	2
Page Range:	S. 258 - 262
Date:	2017
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAXILLARY SINUS; PARANASAL SINUSES; NASAL CAVITY; CANCER; CARCINOMA; TUMORS; ADENOCARCINOMA; MANAGEMENT; RESECTION; HEAD Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24051