Haverkampf, Sonja, Heider, Judith, Weiss, Katharina T., Berneburg, Mark, Karrer, Sigrid, Schreml, Stephan ORCID: 0000-0002-2820-1942, Haubner, Frank, Ettl, Tobias, Schreml, Julia, Hedtrich, Sarah, von Suesskind-Schwendi, Marietta and Dissemond, Joachim (2017). NHE1 expression at wound margins increases time-dependently during physiological healing. Exp. Dermatol., 26 (2). S. 124 - 127. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-0625

Full text not available from this repository.

Abstract

Wound repair is an orchestrated process, encompassing the phases of inflammation, proliferation and tissue remodeling. In this context, sodium hydrogen exchanger 1 (NHE1) is crucial to epidermal barrier integrity and acidification. Recently, we found that extracellular pH (pHe) on wound surfaces is dramatically increased initially after barrier disruption, and that pHe decreases gradually during physiological healing. Additionally, we have shown that spatial NHE1-patterns account for pHe-gradients on surfaces of chronic wounds. Here, we show that NHE1-expression is very low at margins initially after wounding and that it increases massively during the time-course of physiolgical healing. This finding is in accordance with the decrease of pHe on wound surfaces, which we reported on in previous works. Thus, we show that NHE1 is an interesting target when it comes to modification of surface pHe on wounds, both acute and chronic, and that NHE1 is time-dependently regulated in physiological healing.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Haverkampf, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heider, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weiss, Katharina T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berneburg, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karrer, SigridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreml, StephanUNSPECIFIEDorcid.org/0000-0002-2820-1942UNSPECIFIED
Haubner, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ettl, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreml, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hedtrich, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Suesskind-Schwendi, MariettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dissemond, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-240924
DOI: 10.1111/exd.13097
Journal or Publication Title: Exp. Dermatol.
Volume: 26
Number: 2
Page Range: S. 124 - 127
Date: 2017
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1600-0625
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REPAIR; DYNAMICSMultiple languages
DermatologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24092

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item