Universität zu Köln

Schlosser, H. A., Thelen, M., Dieplinger, G., von Bergwelt-Baildon, A., Garcia-Marquez, M., Reuter, S., Shimabukuro-Vornhagen, A., Wennhold, K., Haustein, N., Buchner, D., Heiermann, N., Kleinert, R., Wahba, R., Ditt, V., Kurschat, C., Cingoz, T., Becker, J., Stippel, D. L. and von Bergwelt-Baildon, M. (2017). Prospective Analyses of Circulating B Cell Subsets in ABO-Compatible and ABO-Incompatible Kidney Transplant Recipients. Am. J. Transplant., 17 (2). S. 542 - 551. HOBOKEN: WILEY. ISSN 1600-6143

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Abstract

Immunosuppressive strategies applied in renal transplantation traditionally focus on T cell inhibition. B cells were mainly examined in the context of antibody-mediated rejection, whereas the impact of antibody-independent B cell functions has only recently entered the field of transplantation. Similar to T cells, distinct B cell subsets can enhance or inhibit immune responses. In this study, we prospectively analyzed the evolution of B cell subsets in the peripheral blood of ABO-compatible (n = 27) and ABO-incompatible (n = 10) renal transplant recipients. Activated B cells were transiently decreased and plasmablasts were permanently decreased in patients without signs of rejection throughout the first year. In patients with histologically confirmed renal allograft rejection, activated B cells and plasmablasts were significantly elevated on day 365. Rituximab treatment in ABO-incompatible patients resulted in long-lasting B cell depletion and in a naive phenotype of repopulating B cells 1 year following transplantation. Acute allograft rejection was correlated with an increase of activated B cells and plasmablasts and with a significant reduction of regulatory B cell subsets. Our study demonstrates the remarkable effects of standard immunosuppression on circulating B cell subsets. Furthermore, the B cell compartment was significantly altered in rejecting patients. A specific targeting of deleterious B cell subsets could be of clinical benefit in renal transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlosser, H. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thelen, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dieplinger, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Marquez, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shimabukuro-Vornhagen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wennhold, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haustein, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiermann, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleinert, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahba, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ditt, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurschat, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cingoz, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, D. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241487
DOI:	10.1111/ajt.14013
Journal or Publication Title:	Am. J. Transplant.
Volume:	17
Number:	2
Page Range:	S. 542 - 551
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-6143
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REGULATORY T-CELLS; ANTIBODY-MEDIATED REJECTION; GRANZYME-B; ALLOGRAFT-REJECTION; RENAL-ALLOGRAFT; B10 CELLS; INDUCTION; IMMUNOSUPPRESSION; BASILIXIMAB; TOLERANCE Multiple languages Surgery; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24148