Grundmann, Hajo, Glasner, Corinna, Albiger, Barbara, Aanensen, David M., Tomlinson, Chris T., Andrasevic, Arjana Tambic, Canton, Rafael, Carmeli, Yehuda, Friedrich, Alexander W., Giske, Christian G., Glupczynski, Youri, Gniadkowski, Marek, Livermore, David M., Nordmann, Patrice, Poirel, Laurent, Rossolini, Gian M., Seifert, Harald, Vatopoulos, Alkiviadis, Walsh, Timothy ORCID: 0000-0003-4315-4096, Woodford, Neil, Monnet, Dominique L., Apfalter, Petra, Hartl, Rainer ORCID: 0000-0002-9007-6089, Glupczynski, Youri, Huang, Te-Din, Strateva, Tanya, Marteva-Proevska, Yuliya ORCID: 0000-0001-7247-7391, Andrasevic, Arjana Tambic, Butic, Iva, Pieridou-Bagatzouni, Despo, Maikanti-Charalampous, Panagiota, Hrabak, Jaroslav ORCID: 0000-0003-1049-6604, Zemlickova, Helena ORCID: 0000-0002-3868-0545, Hammerum, Anette, Jakobsen, Lotte, Ivanova, Marina, Pavelkovich, Anastasia, Jalava, Jari, Osterblad, Monica, Vaux, Sophie, Dortet, Laurent, Kaase, Martin, Gatermann, Soeren G, Vatopoulos, Alkiviadis, Tryfinopoulou, Kyriaki, Toth, Akos, Janvari, Laura, Boo, Teck Wee, McGrath, Elaine, Pantosti, Annalisa ORCID: 0000-0002-8409-4731, Monaco, Monica, Balode, Arta, Saule, Mara, Miciuleviciene, Jolanta, Mierauskaite, Aiste, Perrin-Weniger, Monique, Reichert, Paul, Nestorova, Nina, Debattista, Sonia, Zabicka, Dorota ORCID: 0000-0001-9386-8885, Literacka, Elzbieta, Canica, Manuela ORCID: 0000-0002-2077-6231, Manageiro, Vera ORCID: 0000-0001-7729-4199, Damian, Maria, Lixandru, Brandusa, Niks, Milan, Schreterova, Eva, Pirs, Mateja, Cerar, Tjasa, Oteo, Jesus ORCID: 0000-0003-3327-8263, Aracil, Belen, Giske, Christian G., Sjostrom, Karin, Woodford, Neil, Hopkins, Katie ORCID: 0000-0001-7279-5322, Wiuff, Camilla, Brown, Derek J., Hardarson, Hordur, Samuelsen, Orjan ORCID: 0000-0002-5525-2614, Haldorsen, Bjorg, Koraqi, Andi, Lacej, Denada, Raka, Lul, Kurti, Arsim, Mijovic, Gordana, Lopicic, Milena, Jelesic, Zora, Trudic, Anika, Kraftandzieva, Ana, Trajkovska-Dokic, Elena, Gur, Deniz, Cakar, Asli, Carmeli, Yehuda and Adler, Amos (2017). Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study. Lancet Infect. Dis., 17 (2). S. 153 - 164. OXFORD: ELSEVIER SCI LTD. ISSN 1474-4457

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Abstract

Background Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. Methods National expert laboratories recruited hospitals with diagnostic capacities, who collected the first ten carbapenem non-susceptible clinical isolates of K pneumoniae or E coli and ten susceptible same-species comparator isolates and pertinent patient and hospital information. Isolates and data were relayed back to national expert laboratories, which made laboratory-substantiated information available for central analysis. Findings Between Nov 1, 2013, and April 30, 2014, 455 sentinel hospitals in 36 countries submitted 2703 clinical isolates (2301 [85%] Kpneurnoniae and 402 (15%) Ecoli). 850 (37%) of 2301 Kpneumoniae samples and 77 (19%) of 402 Ecoli samples were carbapenemase (KPC, NDM, OXA-48-like, or VIM) producers. The ratio of K pneumoniae to E coli was 11:1.1.3 patients per 10000 hospital admissions had positive clinical specimens. Prevalence differed greatly, with the highest rates in Mediterranean and Balkan countries. Carbapenemase-producing K pneumoniae isolates showed high resistance to last-line antibiotics. Interpretation This initiative shows an encouraging commitment by all participants, and suggests that challenges in the establishment of a continent-wide enhanced sentinel surveillance for carbapenemase-producing Entero-bacteriaeceae can be overcome. Strengthening infection control efforts in hospitals is crucial for controlling spread through local and national health care networks.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Grundmann, HajoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glasner, CorinnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albiger, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aanensen, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomlinson, Chris T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrasevic, Arjana TambicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canton, RafaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carmeli, YehudaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friedrich, Alexander W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giske, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glupczynski, YouriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gniadkowski, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Livermore, David M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordmann, PatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poirel, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rossolini, Gian M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vatopoulos, AlkiviadisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, TimothyUNSPECIFIEDorcid.org/0000-0003-4315-4096UNSPECIFIED
Woodford, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monnet, Dominique L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apfalter, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartl, RainerUNSPECIFIEDorcid.org/0000-0002-9007-6089UNSPECIFIED
Glupczynski, YouriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, Te-DinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strateva, TanyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marteva-Proevska, YuliyaUNSPECIFIEDorcid.org/0000-0001-7247-7391UNSPECIFIED
Andrasevic, Arjana TambicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butic, IvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pieridou-Bagatzouni, DespoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maikanti-Charalampous, PanagiotaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hrabak, JaroslavUNSPECIFIEDorcid.org/0000-0003-1049-6604UNSPECIFIED
Zemlickova, HelenaUNSPECIFIEDorcid.org/0000-0002-3868-0545UNSPECIFIED
Hammerum, AnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakobsen, LotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanova, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pavelkovich, AnastasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jalava, JariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osterblad, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaux, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dortet, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaase, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gatermann, Soeren GUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vatopoulos, AlkiviadisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tryfinopoulou, KyriakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toth, AkosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janvari, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boo, Teck WeeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGrath, ElaineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantosti, AnnalisaUNSPECIFIEDorcid.org/0000-0002-8409-4731UNSPECIFIED
Monaco, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balode, ArtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saule, MaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miciuleviciene, JolantaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mierauskaite, AisteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perrin-Weniger, MoniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichert, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nestorova, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debattista, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zabicka, DorotaUNSPECIFIEDorcid.org/0000-0001-9386-8885UNSPECIFIED
Literacka, ElzbietaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canica, ManuelaUNSPECIFIEDorcid.org/0000-0002-2077-6231UNSPECIFIED
Manageiro, VeraUNSPECIFIEDorcid.org/0000-0001-7729-4199UNSPECIFIED
Damian, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lixandru, BrandusaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niks, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schreterova, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pirs, MatejaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cerar, TjasaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oteo, JesusUNSPECIFIEDorcid.org/0000-0003-3327-8263UNSPECIFIED
Aracil, BelenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giske, Christian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sjostrom, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woodford, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hopkins, KatieUNSPECIFIEDorcid.org/0000-0001-7279-5322UNSPECIFIED
Wiuff, CamillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brown, Derek J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hardarson, HordurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samuelsen, OrjanUNSPECIFIEDorcid.org/0000-0002-5525-2614UNSPECIFIED
Haldorsen, BjorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koraqi, AndiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lacej, DenadaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raka, LulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kurti, ArsimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mijovic, GordanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopicic, MilenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jelesic, ZoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trudic, AnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraftandzieva, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trajkovska-Dokic, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gur, DenizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cakar, AsliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carmeli, YehudaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adler, AmosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-241809
DOI: 10.1016/S1473-3099(16)30257-2
Journal or Publication Title: Lancet Infect. Dis.
Volume: 17
Number: 2
Page Range: S. 153 - 164
Date: 2017
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1474-4457
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SUSCEPTIBILITY; RESISTANCE; HOSPITALS; OUTBREAK; KPC-3Multiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24180

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