Ruppert, Manuela, Franz, Mirjam, Saratsis, Anastasios ORCID: 0000-0003-3302-2145, Escarcena, Laura Velo, Hendrich, Oliver, Gooi, Li Ming, Schwenkert, Isabell, Klebes, Ansgar and Scholz, Henrike (2017). Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce. Cell Reports, 18 (2). S. 533 - 545. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. To understand how cellular stress changes neuronal function, we analyzed Hangover function on a cellular and neuronal level. We provide evidence that Hangover acts as a nuclear RNA binding protein and we identified the phosphodiesterase 4d ortholog dunce as a target RNA. We generated a transcript-specific dunce mutant that is impaired not only in ethanol tolerance but also in the cellular stress response. At the neuronal level, Dunce and Hangover are required in the same neuron pair to regulate experience-dependent motor output. Within these neurons, two cyclic AMP (cAMP)-dependent mechanisms balance the degree of tolerance. The balance is achieved by feedback regulation of Hangover and dunce transcript levels. This study provides insight into how nuclear Hangover/RNA signaling is linked to the cytoplasmic regulation of cAMP levels and results in neuronal adaptation and behavioral changes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ruppert, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franz, MirjamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saratsis, AnastasiosUNSPECIFIEDorcid.org/0000-0003-3302-2145UNSPECIFIED
Escarcena, Laura VeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hendrich, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gooi, Li MingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwenkert, IsabellUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klebes, AnsgarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholz, HenrikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-242599
DOI: 10.1016/j.celrep.2016.12.048
Journal or Publication Title: Cell Reports
Volume: 18
Number: 2
Page Range: S. 533 - 545
Date: 2017
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 2211-1247
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CYCLIC-AMP PHOSPHODIESTERASE; DROSOPHILA-MELANOGASTER; ETHANOL TOLERANCE; MEMORY; GENE; SYSTEM; LOCALIZATION; INHIBITION; ALCOHOLISM; DEPENDENCEMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24259

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