Universität zu Köln

Erdogan, Alican J. and Riemer, Jan (2017). Mitochondrial disulfide relay and its substrates: mechanisms in health and disease. Cell Tissue Res., 367 (1). S. 59 - 73. NEW YORK: SPRINGER. ISSN 1432-0878

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Abstract

Eukaryotic cells harbor membrane-enclosed compartments to spatially separate different biochemical processes. As a result, proteins that become synthesized in the cytosol but fulfill their function in another compartment require translocation machineries. In the intermembrane space (IMS) of mitochondria, the mitochondrial disulfide relay is responsible for the import of many soluble proteins in an oxidation-dependent manner. These IMS proteins carry out important tasks and therefore their import, folding and maintenance are crucial for the remainder of the cell. In this review, we first describe the machinery for oxidative protein folding in the IMS and then focus on recent developments, which especially concern the mammalian machinery, its substrates and its physiological role.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erdogan, Alican J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemer, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243059
DOI:	10.1007/s00441-016-2481-z
Journal or Publication Title:	Cell Tissue Res.
Volume:	367
Number:	1
Page Range:	S. 59 - 73
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0878
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APOPTOSIS-INDUCING FACTOR; CYTOCHROME-C-OXIDASE; SMALL TIM PROTEINS; DEPENDENT SULFHYDRYL OXIDASE; OXIDATIVE FOLDING PATHWAY; DYSTONIA PEPTIDE-1 DDP1; SPACE RECEPTOR MIA40; COPPER CHAPERONE CCS; EMBRYONIC STEM-CELLS; INTERMEMBRANE SPACE Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24305