Universität zu Köln

Todorova, Vyara and Blokland, Arjan (2017). Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System. Curr. Neuropharmacol., 15 (1). S. 166 - 174. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-6190

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Abstract

Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of learning and memory. Mitochondria are involved in the regulation of the complex processes of synaptic plasticity. This paper reviews the current knowledge on the regulatory roles of mitochondria in the function and plasticity of synapses and the implications of mitochondrial dysfunctions in synaptic transmission. First, the importance of mitochondrial distribution and motility for maintenance and strengthening of dendritic spines, but also for new spines/synapses formation is presented. Secondly, the major mitochondrial functions as energy supplier and calcium buffer organelles are considered as possible explanation for their essential and regulatory roles in neuronal plasticity processes. Thirdly, the effects of synaptic potentiation on mitochondrial gene expression are discussed. And finally, the relation between age-related alterations in synaptic plasticity and mitochondrial dysfunctions is considered. It appears that memory loss and neurodegeneration during aging are related to mitochondrial (dys)function. Although, it is clear that mitochondria are essential for synaptic plasticity, further studies are indicated to scrutinize the intracellular and molecular processes that regulate the functions of mitochondria in synaptic plasticity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Todorova, Vyara UNSPECIFIED UNSPECIFIED UNSPECIFIED Blokland, Arjan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243205
DOI:	10.2174/1570159X14666160414111821
Journal or Publication Title:	Curr. Neuropharmacol.
Volume:	15
Number:	1
Page Range:	S. 166 - 174
Date:	2017
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1875-6190
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM POTENTIATION; RAT HIPPOCAMPAL SLICE; ENERGY-METABOLISM; DENDRITIC MITOCHONDRIA; ENDOPLASMIC-RETICULUM; SIGNALING PATHWAYS; CORTICAL-NEURONS; BRAIN; CALCIUM; CELLS Multiple languages Neurosciences; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24320