Universität zu Köln

O'Halloran, Ken D. and Lewis, Philip (2017). Respiratory muscle dysfunction in animal models of hypoxic disease: antioxidant therapy goes from strength to strength. Hypoxia, 5. S. 75 - 85. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 2324-1128

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Abstract

The striated muscles of breathing play a critical role in respiratory homeostasis governing blood oxygenation and pH regulation. Upper airway dilator and thoracic pump muscles retain a remarkable capacity for plasticity throughout life, both in health and disease states. Hypoxia, whatever the cause, is a potent driver of respiratory muscle remodeling with evidence of adaptive and maladaptive outcomes for system performance. The pattern, duration, and intensity of hypoxia are key determinants of respiratory muscle structural-, metabolic-, and functional responses and adaptation. Age and sex also influence respiratory muscle tolerance of hypoxia. Redox stress emerges as the principal protagonist driving respiratory muscle malady in rodent models of hypoxic disease. There is a growing body of evidence demonstrating that antioxidant intervention alleviates hypoxia-induced respiratory muscle dysfunction, and that N-acetyl cysteine, approved for use in humans, is highly effective in preventing hypoxia-induced respiratory muscle weakness and fatigue. We posit that oxygen homeostasis is a key driver of respiratory muscle form and function. Hypoxic stress is likely a major contributor to respiratory muscle malaise in diseases of the lungs and respiratory control network. Animal studies provide an evidence base in strong support of the need to explore adjunctive antioxidant therapies for muscle dysfunction in human respiratory disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code O'Halloran, Ken D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243462
DOI:	10.2147/HP.S141283
Journal or Publication Title:	Hypoxia
Volume:	5
Page Range:	S. 75 - 85
Date:	2017
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	2324-1128
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC INTERMITTENT HYPOXIA; UPPER AIRWAY MUSCLE; ESTROGEN-RECEPTORS EXPRESSION; INDUCED DIAPHRAGMATIC FATIGUE; CHRONIC HYPOBARIC HYPOXIA; APNEA HYPOPNEA SYNDROME; CONTRACTILE PROPERTIES; SEX-DIFFERENCES; RAT DIAPHRAGM; SLEEP-APNEA Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24346