Universität zu Köln

Shiraliyeva, Naila, Friedrichs, Jacqueline, Buettner, Reinhard and Friedrichs, Nicolaus (2017). PD-L1 expression in HNPCC-associated colorectal cancer. Pathol. Res. Pract., 213 (12). S. 1552 - 1556. JENA: ELSEVIER GMBH, URBAN & FISCHER VERLAG. ISSN 0344-0338

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Abstract

Background: PD-L1 immunohistochemistry is predictive for molecular inhibitors of PD-1/PD-L1 immune checkpoint. Therefore, this study evaluated the PD-L1 expression in patients with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). Methods: Immunohistochemical expression of PD-L1 in carcinoma cells, stromal macrophages and lymphocytes of 40 HNPCC-patients with colorectal cancer was scored semi-quantitatively. Results: Focal (2 cases) to extensive (2 cases) PD-L1-immunopositivity of carcinoma cells was detected in 4 out of 40 cases (10.0%). Stromal macrophages were immunopositive in 28 out of 40 cases (70.0%). Lymphocytes showed PD-L1 expression in 3 out of 40 cases (7.5%). Simultaneous immunopositivity of stromal macrophages and tumor cells was detected in two MLH1/PMS2-deficient and two MSH2/MSH6-deficient cases. Conclusion: A subset of HNPCC-associated colorectal cancers in this study clearly showed PD-L1 expression of tumor epithelia and immune cells, therefore, the detection of PD-L1 status is useful.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shiraliyeva, Naila UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrichs, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrichs, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-244648
DOI:	10.1016/j.prp.2017.09.012
Journal or Publication Title:	Pathol. Res. Pract.
Volume:	213
Number:	12
Page Range:	S. 1552 - 1556
Date:	2017
Publisher:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Place of Publication:	JENA
ISSN:	0344-0338
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRUS-ASSOCIATED MALIGNANCIES; CELL LUNG-CANCER; MICROSATELLITE INSTABILITY; SQUAMOUS-CELL; MANAGEMENT; LYMPHOMAS; MUTATION; MLH1; MSH2 Multiple languages Pathology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24464