Caramoy, Albert and Heindl, Ludwig M. (2017). Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography - implications for designing clinical trials. Clin. Ophthalmol., 11. S. 1835 - 1840. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1177-5483
Full text not available from this repository.Abstract
Aim: The aim was to study the variability of choroidal scleral interface (CSI) thickness in healthy subjects and its relevance for designing future studies. Methods: A total of 123 volunteers were imaged using swept-source optical coherence tomography. Early treatment diabetic retinopathy grid was used. Results: Mean central retinal thickness was 285.85 +/- 14.53 mu m and 287.18 +/- 12.93 mu m, and mean central CSI thickness was 273.94 +/- 77.77 mu m and 271.19 +/- 78.85 mu m for the right and left eyes, respectively. Mean retinal and CSI thicknesses correlated negatively with age (p= 0.023, r=-0.208 and p < 0.0001, r=-0.426, respectively) and axial length (p= 0.016, r=-0.220 and p < 0.0001, r=-0.504, respectively). To detect a CSI change of at least 112 mu m, a sample size of 11 or 36 per group is needed for a single-or double-arm study, respectively (a=0.05, power =0.90, no loss to follow- up, assuming standard deviation in future studies as 100 mu m). Conclusion: Future clinical studies using CSI as end point are possible with regard to sample size needed.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-245285 | ||||||||||||
DOI: | 10.2147/OPTH.S145932 | ||||||||||||
Journal or Publication Title: | Clin. Ophthalmol. | ||||||||||||
Volume: | 11 | ||||||||||||
Page Range: | S. 1835 - 1840 | ||||||||||||
Date: | 2017 | ||||||||||||
Publisher: | DOVE MEDICAL PRESS LTD | ||||||||||||
Place of Publication: | ALBANY | ||||||||||||
ISSN: | 1177-5483 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/24528 |
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