Caramoy, Albert and Heindl, Ludwig M. (2017). Variability of choroidal and retinal thicknesses in healthy eyes using swept-source optical coherence tomography - implications for designing clinical trials. Clin. Ophthalmol., 11. S. 1835 - 1840. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1177-5483

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Abstract

Aim: The aim was to study the variability of choroidal scleral interface (CSI) thickness in healthy subjects and its relevance for designing future studies. Methods: A total of 123 volunteers were imaged using swept-source optical coherence tomography. Early treatment diabetic retinopathy grid was used. Results: Mean central retinal thickness was 285.85 +/- 14.53 mu m and 287.18 +/- 12.93 mu m, and mean central CSI thickness was 273.94 +/- 77.77 mu m and 271.19 +/- 78.85 mu m for the right and left eyes, respectively. Mean retinal and CSI thicknesses correlated negatively with age (p= 0.023, r=-0.208 and p < 0.0001, r=-0.426, respectively) and axial length (p= 0.016, r=-0.220 and p < 0.0001, r=-0.504, respectively). To detect a CSI change of at least 112 mu m, a sample size of 11 or 36 per group is needed for a single-or double-arm study, respectively (a=0.05, power =0.90, no loss to follow- up, assuming standard deviation in future studies as 100 mu m). Conclusion: Future clinical studies using CSI as end point are possible with regard to sample size needed.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Caramoy, AlbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heindl, Ludwig M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-245285
DOI: 10.2147/OPTH.S145932
Journal or Publication Title: Clin. Ophthalmol.
Volume: 11
Page Range: S. 1835 - 1840
Date: 2017
Publisher: DOVE MEDICAL PRESS LTD
Place of Publication: ALBANY
ISSN: 1177-5483
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AGEMultiple languages
OphthalmologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24528

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