Universität zu Köln

Braegelmann, Johannes, Boehm, Stefanie, Guthrie, Matthew R., Mollaoglu, Gurkan ORCID: 0000-0003-0679-7463, Oliver, Trudy G. and Sos, Martin L. (2017). Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle, 16 (16). S. 1489 - 1499. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1551-4005

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Abstract

Small cell lung cancer (SCLC) is one of the most deadly cancers and currently lacks effective targeted treatment options. Recent advances in the molecular characterization of SCLC has provided novel insight into the biology of this disease and raises hope for a paradigm shift in the treatment of SCLC. We and others have identified activation of MYC as a driver of susceptibility to Aurora kinase inhibition in SCLC cells and tumors that translates into a therapeutic option for the targeted treatment of MYC-driven SCLC. While MYC shares major features with its paralogs MYCN and MYCL, the sensitivity to Aurora kinase inhibitors is unique for MYC-driven SCLC. In this review, we will compare the distinct molecular features of the 3 MYC family members and address the potential implications for targeted therapy of SCLC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Braegelmann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehm, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Guthrie, Matthew R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollaoglu, Gurkan UNSPECIFIED orcid.org/0000-0003-0679-7463 UNSPECIFIED Oliver, Trudy G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sos, Martin L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-245698
DOI:	10.1080/15384101.2017.1339849
Journal or Publication Title:	Cell Cycle
Volume:	16
Number:	16
Page Range:	S. 1489 - 1499
Date:	2017
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1551-4005
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SMALL-MOLECULE INHIBITORS; MESSENGER-RNA STABILITY; RIBOSOMAL-PROTEIN L11; DNA-DAMAGE RESPONSE; C-MYC; N-MYC; AURORA KINASE; NEUROENDOCRINE TUMORS; GENE-EXPRESSION; MOUSE MODELS Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24569